AASK AFRICAN AMERICAN STUDY OF PATIENTS WITH HYPERTENSION-RELATED KIDNEY DISE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 AASK（非裔美国人高血压相关肾病患者研究）队列研究将是AASK研究的扩展。后一项研究检查了两种不同水平的血压控制和三种不同类型的血压药物对患有高血压引起的肾脏疾病的非裔美国人肾衰竭进展和其他临床结局的影响。本研究现已结束，并决定为AASK研究中的患者提供继续参与研究的机会，该研究仅用于继续监测患者。患者将根据标准药物治疗和个人医生的判断接受高血压和肾病治疗。目前，Kopple博士是唯一一位看到患有慢性肾脏疾病并且没有接受透析或移植治疗的AASK患者的医生。本研究的研究工作将完全限于监测患者。监测的关键要素将包括每年对研究诊所的两次主要访视和两到四次额外的访视，以管理患者的血压。在两次主要的访问中，患者将填写有关其健康状况的问卷，并抽取血液进行各种血液检查。在第一年、第三年和第五年，将分别进行一次指甲剪，并进行超声心动图和动态血压监测。如果患者同意，也将抽取一次血液进行基因检测;在进行基因检测之前，需要使用单独的附加同意书的书面知情同意书。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The AASK (African American Study of Patients with Hypertension-Related Kidney Disease) Cohort Study will be an extension of the AASK Study. This latter study examined the effects of two different levels of blood pressure control and three different types of blood pressure medicines on the progression of kidney failure and other clinical outcomes in African Americans with hypertension-caused kidney disease. This study has now ended, and it has been decided to offer the patients in the AASK Study the opportunity to remain in a study which will do no more than continue to monitor the patients. The patients will receive treatment for their hypertension and kidney disease according to the standard medical therapy and to judgement of their individual physician. Currently, Dr. Kopple is the only physician seeing the AASK patients who have chronic kidney disease and who are not treated with either dialysis or transplantation. The research effort in this study will be limited entirely to monitoring the patients. The key elements of the monitoring will include two main visits to the research clinic each year and two to four additional visits to manage the patients blood pressure. At the two main visits, patients will fill out questionnaires about their health and have blood drawn for various blood tests. Once, fingernail clippings will be obtained and an echocardiogram and ambulatory blood pressure monitoring will each be conducted in the first, third and fifth years. If patients agree, blood will also be drawn on one occasion for genetic testing; a written informed consent using a separate, additional consent form will be required before the genetic testing is done.