AASK AFRICAN AMERICAN STUDY OF PATIENTS WITH HYPERTENSION-RELATED KIDNEY DISE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 AASK(高血压相关肾脏疾病患者的非裔美国人研究)队列研究将是AASK研究的延伸。后一项研究考察了两种不同水平的血压控制和三种不同类型的降压药对患有高血压引起的肾脏疾病的非裔美国人肾衰竭进展和其他临床结果的影响。这项研究现在已经结束，已经决定为AASK研究中的患者提供留在研究中的机会，该研究只会继续监测患者。患者的高血压和肾脏疾病将按照标准的药物治疗并根据各自医生的判断接受治疗。目前，Kopple博士是唯一一位看过AASK患者的医生，这些患者患有慢性肾脏疾病，既没有接受透析治疗，也没有接受移植治疗。这项研究的努力将完全限于监测患者。监测的主要内容将包括每年对研究诊所进行两次主要访问，以及额外访问两到四次以控制患者的血压。在两次主要的就诊中，患者将填写关于他们健康状况的问卷，并抽取血液进行各种血液测试。一次，将获得指甲切片，并在第一、三、五年分别进行超声心动图和动态血压监测。如果患者同意，还将在一次抽血进行基因检测；在进行基因检测之前，需要使用单独的、额外的同意书进行书面知情同意。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The AASK (African American Study of Patients with Hypertension-Related Kidney Disease) Cohort Study will be an extension of the AASK Study. This latter study examined the effects of two different levels of blood pressure control and three different types of blood pressure medicines on the progression of kidney failure and other clinical outcomes in African Americans with hypertension-caused kidney disease. This study has now ended, and it has been decided to offer the patients in the AASK Study the opportunity to remain in a study which will do no more than continue to monitor the patients. The patients will receive treatment for their hypertension and kidney disease according to the standard medical therapy and to judgement of their individual physician. Currently, Dr. Kopple is the only physician seeing the AASK patients who have chronic kidney disease and who are not treated with either dialysis or transplantation. The research effort in this study will be limited entirely to monitoring the patients. The key elements of the monitoring will include two main visits to the research clinic each year and two to four additional visits to manage the patients blood pressure. At the two main visits, patients will fill out questionnaires about their health and have blood drawn for various blood tests. Once, fingernail clippings will be obtained and an echocardiogram and ambulatory blood pressure monitoring will each be conducted in the first, third and fifth years. If patients agree, blood will also be drawn on one occasion for genetic testing; a written informed consent using a separate, additional consent form will be required before the genetic testing is done.