EXERCISE REHABILITATION IN PULMONARY ARTERIAL HYPERTENSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是确定运动康复计划对肺动脉高压患者的安全性和有效性。 这项研究将招募16名患者参加拟议的试验。所有患者都将在基线时进行血液测试，并在基线时接受6分钟步行测试和CPET(最大限度地增加工作量)，以检查他们的肺动脉高压如何影响他们在运动后向肌肉输送氧气的能力。所有患者还将完成一份问卷，以评估他们的生活质量(SF-36问卷)，并将进行第二次CPET(恒定工作负荷，至疲劳)。患者将在J-4的医生和理疗师的监督下接受为期6周的正式运动训练，J-4是一家拥有完善的短期高强度运动训练方案的设施。6周后，再次进行CPETS、问卷调查和血检。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine the safety and efficacy of an exercise rehabilitation program in patients with pulmonary arterial hypertension (PAH). This study will recruit 16 patients for participation in the proposed trial. All patients will have a blood test at baseline and undergo 6-minute walk testing and CPET (increasing workload, to maximum) at baseline in order to examine how their pulmonary hypertension affects their ability to deliver oxygen to their muscles in response to exercise. All patients will also complete a questionnaire to rate their quality of life (SF-36 questionnaire), and will have a second CPET (constant workload, to fatigue). Patients will undergo formal exercise training for 6 weeks under the supervision of a physician and physical therapist in J-4, a facility that has a well-established protocol for intensive, short duration exercise training. AFter 6 weeks, the CPEts, questionnaire, and blood tests will be repeated.