METABOLIC EFFECTS OF ANDROGENICITY IN AGING MEN AND WOMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标 第一章 确定睾酮替代治疗与雌激素替代治疗相比，频繁采样的静脉葡萄糖耐量试验得出的胰岛素敏感性指数是否更高。 （二） 确定在老年男性中，睾酮水平的增加是否是胰岛素敏感性的一个重要预测因子。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS 1) To determine whether the insulin sensitivity index derived from a frequently sampled intravenous glucose tolerance test will be greater with testosterone replacement compared to estrogen replacement. 2) To determine whether an increase in testosterone levels is a significant predictor of insulin sensitivity in older men when accounting for central adiposity.