AGE AND SYMPATHETIC COTRANSMITTER FUNCTION IN HUMAN SKIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们提出的研究旨在系统地研究交感神经递质在人体皮肤中储存、释放和受体结合的神经和血管机制。此外，我们打算在老年受试者中补充BH4和外源性抗坏血酸，以潜在地改善血管收缩功能。拟议的研究将是用于即将到来的竞争NIH R01更新的试点工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our proposed studies intend to systematically investigate neuronal and vascular mechanisms of sympathetic neurotransmitter storage, release, and receptor binding in human skin. Also, we intend to supplement BH4 and ascorbate exogenously in aged subjects to potentially ameliorate vasoconstrictor function. The proposed studies will be pilot work used for an upcoming competitive NIH R01 renewal.