LEVOTHYROXINE PHARMACOKINETICS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 将在补充甲状腺功能减退症的非妊娠和妊娠女性中进行左甲状腺素（LT 4）的药代动力学研究。 充足的甲状腺素对胎儿大脑发育至关重要。 甲状腺功能减退的妇女需要得到充分的补充，特别是在怀孕期间，由于正常的甲状腺素水平在怀孕期间增加。 我们将检查妊娠前（或产后）和妊娠女性（妊娠早期）的LT 4 PK。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pharmacokinetics of levothyroxine (LT4) will be conducted in supplemented hypothyroid non-pregnant and pregnant women. Adequate thyroxine is critical for fetal brain development. Hypothyroid women need to be supplemented adequately especially during pregnancy due to normal increased levels of thyroxine during pregnancy. We will examine LT4 PK in pre-pregnant (or post partum) and pregnant women (1st trimester).