LEVOTHYROXINE PHARMACOKINETICS
LEVOTHYROXINE PHARMACOKINETICS
批准号:
7608465
负责人:
Offie P Soldin
金额:
$16.43万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-03-31
关键词:
Computer Retrieval of Information on Scientific Projects DatabaseDevelopmentDiscipline of obstetricsDoseDrug KineticsFetusFundingGrantInstitutionLabelLevothyroxine SodiumMethodologyNewborn InfantPatient currently pregnantPharmaceutical PreparationsPharmacologyPostpartum PeriodPregnancyPregnant WomenRandomizedResearchResearch PersonnelResourcesSourceStagingSupplementationTestingThinkingThyroid HormonesThyroxineUnited States National Institutes of HealthVisitWeekWomanpreventprospectiveradiation effectstable isotope
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This study, funded by the Obstetrics and Pharmacology Research Unit of NlCHD, is a prospective, multi-center, open-label, non-randomized, pharmacokinetic study before pregnancy, during pregnancy and the postpartum period. Pharmacokinetics of levothyroxine (LT4) will be conducted in supplemented hypothyroid non-pregnant and pregnant women. Synthetic levothyroxine sodium (LT4) supplementation
may need to be increased throughout pregnancy. Since Thyroid Hormone concentration increases by approximately 50% by Gestational Week 6 it is thought that supplementation should be increased by at least 50%. However, little is known regarding the appropriate LT4 dosing in pregnancy, and whether
dosing should change throughout the different stages of gestation to optimize efficacy. Secondly, the minimal LT4 supplementation needed to prevent adverse neuro-developmental effects in the fetus is not known. The PIs propose to investigate LT4 single dose pharmacokinetics using stable isotope
methodology. Women participating in this study will continue on their normal medication. They will also be given a special marker called a "stable isotope" so that the study team can follow fevothyroxine supplementation. The stable isotope will be given only once during the pre-pregnancy {or post-partum) visit and once during the pregnancy visit. Stable isotopes have no harmful or radiation effects; tests
have shown them to be safe in newborn infants and they have been used for over 20 years in studies
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Hyopthyroidism Treatment in Aging and Thyroid Cancer
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批准号:8133389
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项目类别:
-
资助金额:$36.89万
-
财政年份:2010
-
负责人:Offie P Soldin
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依托单位:
Hyopthyroidism Treatment in Aging and Thyroid Cancer
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批准号:7987882
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项目类别:
-
资助金额:$38.38万
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财政年份:2010
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负责人:Offie P Soldin
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依托单位:
Hyopthyroidism Treatment in Aging and Thyroid Cancer
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批准号:8318708
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项目类别:
-
资助金额:$36.89万
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财政年份:2010
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负责人:Offie P Soldin
-
依托单位:
LEVOTHYROXINE PHARMACOKINETICS
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批准号:7951986
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项目类别:
-
资助金额:$2.08万
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财政年份:2009
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负责人:Offie P Soldin
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依托单位:
LEVOTHYROXINE PHARMACOKINETICS
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批准号:7719054
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项目类别:
-
资助金额:$3.71万
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财政年份:2008
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负责人:Offie P Soldin
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依托单位:
TOBACCO SMOKE EXPOSURE AND HORMONAL CHANGES IN WOMEN
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批准号:7608466
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项目类别:
-
资助金额:$5.48万
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财政年份:2007
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负责人:Offie P Soldin
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依托单位:
TOBACCO SMOKE EXPOSURE AND HORMONAL CHANGES IN WOMEN
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批准号:7608330
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项目类别:
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资助金额:$0.19万
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财政年份:2006
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负责人:Offie P Soldin
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依托单位:
国内基金
海外基金
水稻边界发育缺陷突变体abnormal boundary development(abd)的基因克隆与功能分析
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批准号:32070202
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项目类别:面上项目
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资助金额:58.0万元
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批准年份:2020
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负责人:汪泉
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依托单位:
Development of a Linear Stochastic Model for Wind Field Reconstruction from Limited Measurement Data
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批准号:--
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项目类别:--
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资助金额:40万元
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批准年份:2020
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负责人:Vikrant Gupta
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依托单位: