KINETIC ANALYSIS OF 13C NMR BRAIN SPECTRA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该合作伙伴关系将致力于开发磁共振成像（MRI）和光谱（MRS）方法，以评估高磁场下的大脑结构和功能。在此之前，范德比尔特小组实施了功能性磁共振成像（fMRI）、扩散张量融合成像（DTI）和图像分析的新方法，并将这些信息与近红外光学地形图和电生理学相结合。这项工作是在3 Tesla上进行的。在新的提案中，戈尔博士的团队旨在优化新的7特斯拉人体扫描仪可获得的图像和光谱的质量，并专注于如何整合和评估来自不同MR技术的信息，以全面了解人类大脑结构和功能。范德比尔特将实施一些与优化7 T下的功能磁共振成像和弥散张量成像相关的目标。 五个目标之一将与本经常资源合作执行。 目标5是通过直接或间接检测方法开发和实施多核MRS方法，特别是注入标记底物后的质子去耦13 C采集，以评估大脑中的代谢物和神经递质动力学。将在范德比尔特进行数据采集，并在实验设计中使用UTSW的输入，并在UTSW的RR堆芯1中分析数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This partnership will pursue developments of magnetic resonance imaging (MRI) and spectroscopic (MRS) methods for assessing brain structure and function at high magnetic fields. Previously, the Vanderbilt group implemented new methods of functional MRI (fMRI), diffusion tensor fusion imaging (DTI), and image analysis, and integrated this information with near infra-red optical topography and electrophysiology. This work was performed at 3Tesla. In the new proposal, Dr. Gore's team aims to optimize the quality of the images and spectra obtainable from a new 7Tesla human scanner and to focus on how to integrate and evaluate the information from different MR techniques into a comprehensive picture of human brain structure and function. There are a number of goals that will be carried out at Vanderbilt related to optimizing fMRI and DTI at 7T. One of the five objectives will be performed in collaboration with this RR. Goal 5 is to develop and implement methods for multinuclear MRS, particularly proton decoupled 13C acquisitions following the infusion of labeled substrates, by direct or indirect detection methods, to assess metabolite and neurotransmitter kinetics in the brain. Data acquisition will be performed at Vanderbilt with input from UTSW in experimental design, and data will be analyzed at UTSW in Core 1 of the RR.