IDENTIFICATION OF SMALL MOLECULES TO TARGET PROKARYOTIC CYTOSKELETAL ELEMENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 小分子分子是研究细菌和真核细胞骨架的重要工具，因为它们使得在体内快速解聚或稳定细丝成为可能。然而，目前只发现了数量有限的以细菌细胞骨架为靶标的小分子。该项目将在Crecentus中发现新的细菌细胞骨架元素的小分子抑制剂。一旦鉴定出来，这些小分子将在实验室中合成，进行进一步的表征。核磁共振将被用来验证这些小分子的纯度和结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Small molecues represent an important tool for studying both bacterial and eukaryotic cytoskeletons because they make it possible to rapidly depolymerize or stabilize a filament in vivo. However, only a limited number of small molecules that target the bacterial cytoskeleton have been identified. This project will identify new small molecule inhibitors of bacterial cytoskeletal elements in C. Crecentus. Once identified, the small molecules will be synthesized in the laboratory for further characterization. NMR will be used to veryify the purity and structure of these small molecules.