EFFECT OF AEROBIC EXERCISE ON BRAIN ACTIVITY FOLLOWING TRAUMATIC BRAIN INJURY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项建议的目标是建立在目前的康复和神经影像学的知识，第一次检查心肺功能和脑活动之间的关系，在创伤性脑损伤（TBI）的人类受试者。本研究的主要目的是确定TBI受试者与正常对照受试者在工作记忆任务期间的皮层活动差异，并确定参与12周有氧运动计划对皮层活动的影响。开展这一研究具有重要的理论意义和现实意义。在理论层面上，这项研究将整合运动科学和神经科学，以加强对心肺适能的远期影响的理解，超越公认的生理效应。从实践和治疗的角度来看，了解有氧运动的好处是否已经在健康和受损的动物和健康人群中看到适用于脑损伤的成年人可能最终导致临床使用有氧训练计划作为TBI后认知康复的有效辅助手段。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to build upon the current knowledge of rehabilitation and neuroimaging by examining for the first time the relationship between cardiorespiratory fitness and brain activity in traumatically brain injured (TBI) human subjects. The primary objectives of this study are to identify differences in the cortical activity of TBI subjects compared to normal control subjects during a working memory task and to ascertain the effect of participating in a 12 week aerobic exercise program on that cortical activity. There is both theoretical and practical significance for conducting this study. On a theoretical level, this study will integrate exercise science and neuroscience to enhance the understanding of the distant effects of cardiorespiratory fitness beyond the commonly acknowledged physiological effects. From a practical and therapeutic perspective, knowing whether the benefits of aerobic exercise already seen within well and impaired animals and healthy human populations applies to brain-injured adults may eventually lead to the clinical use of aerobic training programs as efficacious adjuncts to cognitive rehabilitation following TBI.