BRAIN ABNORMALITIES IN ADOLESCENT OBESITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目前的研究建议使用多种MRI技术(结构、扩散张量、功能MRI和灌注)和神经认知评估，以彻底表征与青少年超重相关的大脑影响和潜在的认知障碍。我们计划使用横截面设计，研究体重正常或肥胖的年轻人。 我们的受试者将从IDEA研究纵向队列研究中招募，该研究使用三个年度数据收集期跟踪年轻人(基线年龄为10-16岁)。具体研究目标和假设如下： 目的1：使用以下磁共振成像技术：1)结构成像；2)扩散张量成像；3)功能磁共振成像；4)灌注磁共振成像，以确定较大的体重与脑变化之间的关系。 目的2：刻画体重对认知的影响。 考虑到青少年肥胖的流行率，以及缺乏明确的脑成像数据，这项研究被认为是及时和必要的。这项调查的结果有望让医学专业人员了解肥胖的大脑机制--最终有助于预防和治疗青少年肥胖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current research proposes to use multiple MRI techniques (structural, diffusion tensor, functional MRI, and perfusion), and neurocognitive assessments, to thoroughly characterize the brain effects, and potential cognitive impairments, associated with excess weight gain in adolescents. We plan to do this using a cross sectional design, studying youths who are either normal-weight or obese. Our subjects will be recruited from the IDEA Study longitudinal cohort study - that follows youth (ages 10-16 at baseline) using three yearly data collection periods. The specific research aims and hypotheses are as follows: Aim 1: Determine how greater body mass is associated with brain changes using the following MRI techniques: 1) Structural Imaging; 2) Diffusion tensor imaging; 3) Functional MRI, and 4) Perfusion MRI. Aim 2: Characterize the effect of body mass on cognition. Considering the pandemic rate of youth obesity, and the lack of explicit brain imaging data available, this research is considered timely and necessary. Results of this investigation are expected to inform medical professionals about the brain mechanisms of obesity - ultimately, towards prevention and treatment of adolescent obesity.