MODELLING HIPPOCAMPUS SUB-STRUCTURES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的小组最近开发了一些分割工具，专门用于来自基本临床MR图像的TLE和AD患者的大脑皮层-杏仁核复合体（Chupin等人，ISBI 2002）。我们有兴趣用脑磁图探测这些更深层次的结构。我们最近获得的植入癫痫患者同时记录在脑磁图中的数据表明这是非常有前途的。我们的工具对海马体和杏仁核信封进行了自动分割。现在我们想开发海马详细内部结构的通用模型。我们的想法是获得海马体的3D模板，带有标记的子结构，我们将变形和扭曲到我们将从个体MR中提取的个体信封。我们偶然发现了Toga教授1994年和1997年关于冷冻切片人脑的论文，并认为您一直使用的部分数据可能会引起我们的极大兴趣。我们可以精确地手动描绘我们感兴趣的结构（海马、杏仁核和邻近的皮质，这些在1997年的论文中已经描述过），并在我们的神经解剖学家专家的帮助下，通过标记感兴趣的子结构来进一步推进。3D镶嵌模型可以与从我们的分割工具获得的整体包络一起设计。这些物体将成为一个3D模板，可以扭曲到从MR扫描中提取的单个信封。这个与LONI的合作项目需要我们访问LONI数据库中的一个冷冻切片大脑及其3D重建的高分辨率图片。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our group has recently developed some segmentation tools dedicated to the hippocampus-amygdala complex in TLE and AD patients from basic clinical MR images (Chupin et al., ISBI2002). We're interested in detecting these deeper structures using MEG. Recent data we've acquired with implanted epileptic patients recorded simultaneously in MEG indicate this is very promising. Our tools run some automatic segmentation of the hippocampus and amygdala envelopes. Now we would like to develop generic models of the hippocampus detailed inner structure. Our idea is to obtain a 3D template of the hippocampus, with labelled sub-structures, that we would deform and warp to the individual envelope we would extract from individual MRs. We came accross Prof Toga's 1994 and 1997 papers dealing with the cryosectioned human brains and thought part of the data you've been using could be of great interest to us. We could precisely delineate manually the structures we are interested in (Hippocampus, Amygdala and adjacent cortices, things that are already described in the 1997 paper) and push this a bit further by labelling some sub-structures of interest with the help of our neuroanatomist expert. 3D tessellated models could be designed together with the overall envelope obtained from our segmentation tool. These objects would become a 3D template that could be warped to the individual envelope extracted from an MR scan.This collaborative project with LONI requires we gain access to the high-resolution pictures of one of the cryosectioned brains and of its 3D reconstruction in LONI's database.