DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们希望将树突棘模型化为兴奋性突触及其相关的亲本树突。虚拟电池以电压敏感的方式模拟离子通量的能力为这样做提供了一个强大而独特的框架。我们的具体目标是建立一个生理上准确的CA1锥体神经元脊髓隔膜：谷氨酸受体(AMPAR、NMDARs)、适当的电压敏感钙通道(CaV3、CaV1.2/1.3和Cav2.2/2.3)和SK通道(细胞内钙依赖)。准确地模拟局部钙的缓冲和扩散也是必要的。我们还希望包括一个与脊柱电和扩散耦合的树枝晶室。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We would like to model a dendritic spine as an excitatory synapse, and its associated parent dendrite. Virtual Cell's ability to model ion flux in a voltage sensitive manner gives a powerful and unique framework to do so. The specific goal would be to model a physiologically accurate CA1 pyramidal neuron spine compartment with the following: glutamate receptors (AMPARs, NMDARs (with voltage dependence)), the appropriate voltage sensitive calcium channels (CaV3, CaV1.2/1.3 and CaV2.2/2.3), and SK channels (with intracellular Ca dependence). It is also necessary to accurately model local Ca buffering and diffusion. We would also like to include a dendrite compartment that is electrically and diffusionally coupled to the spine.