Bracing the Patellofemoral Osteoarthritis: A Clinical Trial

骨关节炎(OA)是一项重大的公共卫生挑战，被列为导致残疾的主要原因 在长辈中。相对较少注意研究或治疗膝骨性关节炎的髌股关节， 尽管有建议，但这种疾病可能与下肢残疾密切相关。 这项建议的具体目标是： 1)进行为期20周的随机交叉临床试验 骨性关节炎，以确定提供髌股支撑是否导致较低的疼痛评分和 与使用安慰剂治疗期间相比，这种治疗期间的功能改善； 2)进行开放式标签跟踪研究，以跟踪治疗的使用和效果。 我们提出了一项双盲、随机交叉试验，为患有以下疾病的患者提供了一种髌股支撑。 以膝关节疼痛为主要结局的膝关节骨性关节炎 运动，以及在参与者指定的加重活动期间的疼痛。这两种治疗方法将是 如下：处理A(对照)，不带甜甜圈(支撑物)的中性支具和重新对准的带子 处理B(主动)，一种髌股支具(DonJoy Tru-Pull高级)。 磨合设计将被用来最大限度地招募将留在试验中的受试者。 受试者将被随机分成A组或B组，为期6周，为期8周。对于每个主题， 审判将持续20周。研究评估将在波士顿大学医学中心GCRC进行。这个 随后将对受试者进行为期6个月的开放标签随访。 最近的估计表明，有症状的膝骨性骨关节炎发生在60岁及以上人群中的13%。那里有 对物理治疗方式的严重忽视，这在一定程度上是药物的后果 发展机遇。需要开发能够改善脑部疾病的治疗方法 骨性关节炎的症状是一个重要的研究对象。这一项目是对一种有希望的 物理治疗方式。该项目的短期结果将是评估膝关节的疗效 为膝骨性关节炎患者的疼痛和残疾做准备。示威的长期结果是 这种干预的效果将是减少由膝骨股骨性关节炎引起的疼痛和残疾。 在更广泛的社区中。

Osteoarthritis (OA) is a significant public health challenge, being ranked as the leading cause of disability in elders. Relatively little heed has been paid to studying or treating the patellofemoral (PF) joint in OA, despite suggestions that disease there may be strongly correlated with lower extremity disability. The specific aims of this proposal are: 1) To undertake a 20 week randomized crossover clinical trial in patients with patellofemoral osteoarthritis to determine whether provision of patellofemoral bracing leads to lower pain scores and improved function during the time of this treatment than during the use of a placebo treatment; 2) To perform an open label follow-up study to track use and effectiveness of treatment. We propose a double blind, randomized crossover trial of a patellofemoral bracing for patients with patellofemoral osteoarthritis with the primary outcome being knee pain as assessed by the VAS scale on movement, and pain during an aggravating activity nominated by the participant. The two treatments will be as follows: TREATMENT A (CONTROL), a neutral brace without the donut (buttress) and realigning strap and TREATMENT B (ACTIVE), a patellofemoral brace (DonJoy Tru-pull advanced). A run-in design will be used to maximize the likelihood of recruiting subjects who will remain in the trial. Subjects will be randomized to treatment A or B for 6 weeks, with an 8 week washout. For each subject, the trial will last 20 weeks. Study evaluation will take place at the Boston University Medical Center GCRC. The subject's will then be followed for 6 months in an open-label follow-up. Recent estimates suggest that symptomatic knee OA occurs in 13% of persons age 60 and over. There has been a remarkable neglect of physical treatment modalities that is, in part, a consequence of drug development opportunities. The need to develop treatment approaches that are capable of ameliorating the symptoms of OA is an important research objective. This project constitutes an attempt to test a promising physical treatment modality. The short-term outcomes of this project will be to assess the efficacy of knee bracing for pain and disability in patellofemoral osteoarthritis. The longer-term outcome of demonstrating efficacy of such an intervention will be to reduce pain and disability arising from patellofemoral osteoarthritis in the wider community.