TULANE COBRE: TRANSGENIC & GENE-TARGETED ANIMAL CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 转基因和基因靶向动物核心设施为基因工程小鼠和大鼠品系的维护和研究提供了宝贵的资源，这将有助于理解高血压的病理生理以及调节血压和心血管疾病状态的分子机制。这一设施将为研究人员提供独特的资源和标准化方法，以确定转基因和基因靶标小鼠的特征。总体而言，动物核心提供了独特的最先进的标准化方法，以进一步表征新型转基因和基因靶向小鼠模型，以研究血压调节和心血管动态平衡。核心帮助支持初级教员调查人员以及几名高级教员的项目。 去年，下列机构使用了转基因核心设施： L·加布里埃尔·纳瓦尔博士，首席研究员 Kailash N.Pandey，博士，主任/导师 肯尼斯·D·米切尔博士，联席主任/导师 Samir El-Dahr，医学博士调查员/导师 Hiro Kbori，医学博士，研究员 哈立德·马特鲁吉，博士研究员 Minolfa Prieto，医学博士，研究员 Zubaida Saifudeen，博士研究员 Ihor V.Yosypiv，医学博士调查员 欧华德，B.S.实验室。研究技术员

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The transgenic and gene-targeted Animal Core Facility serves as a valuable resource for the maintenance and study of genetically engineered mouse and the rat strains that will contribute to the understanding of the pathophysiology of hypertension and the molecular mechanisms regulating blood pressure and cardiovascular disease states. This facility will provide investigators access to unique resources and standardized methods to characterize transgenic and gene-targeted mice. Overall, the animal core provides access to unique state-of-the-art standardized methods to further characterize the novel transgenic and gene-targeted mouse models to study the blood pressure regulation and cardiovascular homeostasis. The core helps support project from junior faculty investigators as well as several of the senior faculty. During the last year, the following used the transgenic core facility: L. Gabriel Navar, Ph.D. Principal Investigator Kailash N. Pandey, Ph.D. Director/Mentor Kenneth D. Mitchell, Ph.D. Co-Director/Mentor Samir El-Dahr, M.D. Investigador/Mentor Hiro Kabori, M.D.,Ph.D. Investigator Khalid Matrougui, Ph.D. Investigator Minolfa Prieto, M.D., Ph.D. Investigator Zubaida Saifudeen, Ph.D. Investigator Ihor V. Yosypiv, M.D. Investigator Edward Au, B.S. Lab. Research Technician