Nuclear Receptors in Liver Health and Disease

描述(由申请人提供)： 需要五年的资金在堪萨斯大学医学中心建立一个生物医学研究卓越中心，重点是核受体及其在肝脏健康和疾病中的作用。五名有同样研究兴趣的有才华的新教员被选中，目的是帮助他们成为有资金支持的独立调查人员。一个由资深教员组成的内部咨询委员会和一个由杰出科学家组成的外部咨询委员会已经成立，以指导他们实现这一目标。该中心还将帮助提供基础设施和设备，以补充研究环境。最终，通过这些初步目标的实现，最终的长期目标是提交以核受体和相关主题为主题的计划项目拨款申请。这项建议的一个重要特点是，为每个初级教员分配了两名共同导师，并制定了个人辅导计划和时间表。指导计划的主要特点包括由导师和国际咨询委员会对研究项目进行持续的批判性评估，与欧洲咨询委员会成员举行半年一次的会议，以及关于统计、手稿和赠款撰写以及教学的特别培训。最初的小组将获得长达三年的支持。在这段时间内，预计每个成员都将成功竞争独立的NIH R01类型的研究支持。一旦获得外部资金，他们将在财政上轮换拨款，为增加新的初级教员腾出空间。在五年内，这笔拨款将支持10-15名独立研究人员。该提案的另一个重要特点是建立五个新的核心能力，为中心的教职员工提供额外的研究支持。这些核心包括行政核心以及分子生物学、空小鼠发育和饲养、表型鉴定能力和生物分析支持等领域的核心。总而言之，科学人才、现有研究环境和所需的新核心设施的出色结合确保了拟建的中心将促进一个专题多学科研究中心的发展，增强新研究人员独立竞争补充NIH和其他外部同行审查支持的能力，并加强KUMC现有的生物医学研究基础设施。

DESCRIPTION (provided by applicant): Five years of funding are requested to develop a Center of Biomedical Research Excellence at Kansas University Medical Center with a focus on Nuclear Receptors and their Role in Liver Health and Disease. Five talented new faculty who share this research interest were selected with the goal of helping them become funded, independent investigators. A PI, co-PI, an internal advisory committee of experienced senior faculty and an external advisory committee of prominent scientists have been assembled to mentor them to this goal. The Center will also help provide infrastructure and equipment to supplement the research environment. Ultimately, through the achievement of these initial goals, the final long-range goal is the submission of a program project grant application centered on the theme of nuclear receptors and related topics. An important feature of this Proposal is that for each initial junior faculty member, two co-mentors have been assigned and individual mentoring plans and timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of the research project by the mentors and IAC, semiannual conferences with EAC members, and special training on statistics, manuscript and grant writing, and teaching. The initial group will receive support for up to three years. Within this time period each member will be expected to compete successfully for independent NIH R01-type research support. Once funded externally, they will financially rotate off the grant to make room for addition of new junior faculty members. Over five years, the grant will support 10-15 independent research investigators. Another important feature of the Proposal is to establish five new Core capabilities to provide additional research support for the Center's faculty. These cores include an administrative Core as well as Cores in the areas of molecular biology, null-mice development and husbandry, phenotyping capabilities, and bioanalytical support. In summary, the outstanding combination of scientific talent, existing research environment, and requested new core facilities ensure that this proposed Center will foster the development of a thematic multi-disciplinary research center, to enhance the ability of new investigators to compete independently for complementary NIH and other external peer-reviewed support, and to strengthen existing biomedical research infrastructure at KUMC.