COBRE: RIH:CORE A: ADMINISTRATION & CAREER DVMT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 CCRD的使命是基于导致胃肠道癌症的细胞和分子途径的原始、协作、多学科实验室研究，创造、解释和应用新知识。 这一广泛的研究领域由研究人员进行与四个主要主题相关的研究-主题A -胎儿蛋白质和表型在癌症中的意义;主题B -胃肠道肿瘤的发病机制;主题C -与致癌相关的信号转导机制;主题D -RNA和DNA病毒在癌症中的作用。 在过去的四年中，CCRD支持的研究范围已经扩大到胃肠道癌之外，现在包括检查与乳腺癌，前列腺癌，肾癌和肺癌相关的分子事件的项目。为了反映这一范围的变化，并强调正在进行的研究的转化潜力，我们的总体主题现在将成为“癌症干预的分子靶点”，这一主题将产生更广泛的基础研究视野，我们认为这将鼓励研究人员找到创造性的方法，将新的见解转化为肿瘤的分子基础，改进诊断和治疗方法。正在考虑的可能的子主题包括：用于预测对治疗反应、预后、分期的生物标志物;使用siRNA、特异性抑制剂等进行分子干预的靶点;靶向增加对常规治疗敏感性的信号通路;环境、生理或感染因子靶向的分子通路。我们将在2006年5月24日的研讨会上向我们的外部咨询委员会介绍这些变化。 COBRE CCRD网站可在www.RIH-COBRE-CARES.org上找到。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The mission of the CCRD is to create, interpret, and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to gastrointestinal cancer. This broad area of research is represented by investigators pursuing research relevant to four major themes - Theme A - The significance of fetal proteins and phenotypes in Cancer; Theme B - Pathogenesis Of GI Tumors; Theme C - Signal Transduction Mechanisms Relevant to Carcinogenesis; Theme D - Role of RNA and DNA Viruses in Cancer. Over the last four years, the scope of research supported by the CCRD has broadened beyond gastrointestinal cancer and now includes projects examining molecular events relevant to breast, prostate, kidney and lung cancer. To reflect this change in scope and to emphasize the translational potential of ongoing research, our overall theme will now become "Molecular Targets for Cancer Intervention", a theme that engenders a broader vision of basic research that we feel will encourage investigators to find creative ways to translate new insights into the molecular basis of neoplasia into improved methods for diagnosis and treatment. Possible sub themes being considered include: Biomarkers for predicting response to therapy, prognosis, staging; Targets for molecular intervention using siRNA, specific inhibitors etc; Targeting signaling pathways that increase sensitivity to conventional treatments; Molecular pathways targeted by environmental, physiological, or infectious agents. We will present these changes to our External Advisory Committee at our May 24, 2006 Symposium. The COBRE CCRD website can be found at www.RIH-COBRE-CARES.org. It lists NCRR funding for this Center.