Animal Facility

威斯塔研究所提供了一个获得AAALC认证的动物设施，为基因系的教师提供服务 表达和调节，肿瘤发生和免疫学癌症中心计划。该设施是 作为改良屏障生物安全2级（BSL 2）设施，由高素质和经验丰富的 人员的除了订购和饲养研究动物外，该设施还设有小鼠遗传学中心。 设施。动物设施支持严重联合免疫缺陷（SCID）小鼠育种 菌落，隔离房，技术培训，活体成像系统（MS）200 i体内成像 能力，动物健康监测，兽医覆盖面，新员工动手培训，以及 机构动物护理和使用委员会（IACUC）测试。自2003年以来，Wistar研究所投资了 超过100万美元用于动物设施的结构升级和支持癌症中心的新设备 程序.一个新的抛光冷却器增加了冷却水的供应，并确保稳定 在最热的天气期间，设施的温度调节，以及 主冷却系统发生故障。设施基础设施的其他升级包括 改善通风、安全和应急能力。直接数字控制监控已经 与所有动物房相结合，提供24小时温度和加热监控， 通风和空调（HVAC）系统。研究基础设施的改进包括增加 IVIS成像仪，允许以高分辨率随时间监测肿瘤生长;最先进的新型生物防护 用于扩大涉及病毒载体和其他传染媒介的研究的设备;以及 转基因小鼠套件用于扩大小鼠遗传学共享设施。未来的目标反映了 癌症研究人员和共享设施的需求，包括购买额外的生物遏制 笼舍设备和II级生物安全柜;麻醉机;小鼠体视显微镜 外科手术;继续升级安保系统。

The Wistar Institute provides an AAALAC-accredited Animal Facility that serves faculty from the Gene Expression and Regulation, Oncogenesis, and Immunology Cancer Center programs. The facility is maintained as a modified barrier Biosafety Level 2 (BSL2) facility by highly qualified and experienced personnel. In addition to ordering and housing research animals, the facility houses the Mouse Genetics Facility. The Animal Facility supports the severe combined immunodeficiency (SCID) mouse breeding colony, quarantine housing, technical training, Intravital Imaging System (MS) 200i in vivo imaging capabilities, animal health surveillance, veterinary coverage, new employee hands-on training, and Institutional Animal Care and Use Committee (IACUC) testing. Since 2003, The Wistar Institute has invested over $1 million into the Animal Facility for structural upgrades and new equipment supporting Cancer Center programs. A new polishing chiller augments chilled water supplies for cooling, and ensures stable temperature regulation for the Facility during the hottest weather, as well as back-up chilled water supplies in the event of failure in the primary cooling system. Additional upgrades to the facility infrastructure include improved ventilation, security, and emergency capabilities. Direct Digital Control monitoring has been incorporated into all animal rooms, offering 24-hour monitoring of the temperature as well as the heating, ventilation, and air condition (HVAC) system. Research infrastructure improvements include the addition of an IVIS imager, permitting tumor growth monitoring over time at high resolution; new state-of-the-art biocontainment equipment for expanding studies involving viral vectors and other infectious agents; and a transgenic mouse suite for use by the expanding Mouse Genetics Shared Facility. Future goals reflect the needs of cancer researchers and shared facilities and include the purchase of additional bio-containment caging equipment and Class II bio-safety cabinets; an anesthesia machine; a stereomicroscope for mouse surgical procedures; and continued upgrades to security systems.