Mouse Models and Cancer Stem Cells

小鼠模型和癌症干细胞计划的科学目标和中心主题是 研究干细胞功能，包括自我更新和分化、生长因子需求和 MicroRNAs，以小鼠、果蝇、非洲爪哇和斑马鱼为模型，目的是了解更多 关于组织和癌症干细胞。此外，已知的发育信号通路是 重新激活并驱动癌细胞表型，包括Wnt/p-catenin，ErbB2和受体 酪氨酸激酶和转化生长因子-β途径正在研究中。遗传模型正在被开发并用于 研究癌症和炎症。 该计划包括来自六个不同实验室的11名成员：Senyon Choe(转化生长因子-J3受体 结构和信号)，弗雷德·盖奇(神经系统中的干细胞自我更新与癌症)，胡安·卡洛斯 Izpisua Belmonte(组织干细胞在发育和癌症中的作用)，Leanne Jones(干细胞本身 更新机制)，Chris Kintner(Notch通路信号在发育中)，Kuo-Fen Lee(ErbB2 受体酪氨酸激酶信号转导)、格雷格·莱姆克(受体酪氨酸激酶信号转导在免疫中的作用 系统)，Samuel Pfaff(发育中的EphA受体酪氨酸激酶信号)，John Thomas(果蝇 胶质母细胞瘤模型)、InderVerma(癌症和慢病毒载体发展的小鼠模型)和John YONG(HTLV感染中的宿主细胞因素)。 上一个预算年度经同行审查的支助(直接费用)总额为7 449 255美元。没有一个 这是来自NCI的直接支持。美国国立卫生研究院和其他联邦政府对这一计划的大力支持在 外部资助研究项目一览表。 在上一次赠款期间(2004-2008年)，该方案成员发表的出版物总数为299份。 在所有出版物中，10%是方案内出版物，11%是方案间出版物(见第8节 解释计划重组如何影响这些数字)。

The scientific goals and central themes of the Mouse Models and Cancer Stem Cells Program are to investigate stem cell function, including self renewal and differentiation, growth factor requirements and microRNAs, using mouse, Drosophila, Xenopus, and zebrafish as models, with the goal of learning more about tissue and cancer stem cells. In addition, developmental signaling pathways that are known to be reactivated and drive the cancer cell phenotype, including the Wnt/p-catenin, ErbB2 and TAM receptor tyrosine kinases, and TGF-P pathways, are being studied. Genetic models are being developed and used to study cancer and inflammation. The program includes eleven members from six different laboratories: Senyon Choe (TGF-J3 receptor structure and signaling), Fred Gage (stem cell self renewal in the nervous system and cancer), Juan Carlos Izpisua Belmonte (tissue stem cell function in development and cancer), Leanne Jones (stem cell self renewal mechanisms), Chris Kintner (Notch pathway signaling in development), Kuo-Fen Lee (ErbB2 receptor tyrosine kinase signaling), Greg Lemke (TAM receptor tyrosine kinase signaling in the immune system), Samuel Pfaff (EphA receptor tyrosine kinase signaling in development), John Thomas (Drosophila glioblastoma model), InderVerma (mouse models of cancer and lentivirus vector development), and John Young (host cell factors in HTLV infection). The total amount of peer-reviewed support (direct costs) for the last budget year was $7,449,255. None of this was from direct NCI support. Substantial NIH and other federal support for this program is outlined in the table of externally funded research projects. The total number of publications by members of this program in the last grant period (2004-2008) was 299. Of the total publications, 10% were intraprogrammatic and 11 % were interprogrammatic (see Section 8 for explanation of how the program reorganization affects these numbers).