Small Animal Imaging Shared Resource

小动物影像共享资源(SAISR)是在年建立的JCCC共享资源 2002年，配备了MicroPET扫描仪原型、MicroCT和数字全身放射自显影(DWBA)系统 和光学成像系统。2002年，12名JCCC教职员工组成了用户基础。在过去五年中 年所有最初的SAISR仪器都已更换；我们目前有一个专门的成像套件， 配备一台新的microCT，两台microPET仪器，一台新的低温恒温器和DWBA系统，三台 生物发光/荧光光学成像仪和Maestro光谱滤光荧光仪 系统。所有工具都是在机构支助下获得的。SAISR有专门的隔膜用于 纵向成像研究。我们的用户群已经发展到44名教职员工，他们的表现超过了14,000 去年的成像实验。来自7个项目领域的JCCC成员完成了86%的研究。 JCCC CCSG对SAISR的支持占SAISR运营预算的14%。2008年，SAISR将 搬进一套新的1500平米的房子。英国《金融时报》位于加州纳米系统研究所大楼的成像实验室。这个设施 将包括专用的间隔室、程序室、微型PETS、微型CT、生物发光、荧光 和DWBA能力以及用于小动物成像研究和回旋加速器的相邻空间 用于放射化学设施。这一新的实体设施是机构支持的有形证明 特别是SAISR和JCCC的一般情况。SAISR是“全方位服务”，提供授课“课堂”。 关于成像仪器和动物处理规程的指导和培训，个人指导，在线 用于成像程序的说明、标准操作规程、在线远程调度 仪器、数据存储和存档、数据检索和数据处理、工作人员现场数据检索 咨询和协助数据处理，所有探针和造影剂用于microPET、microCT和 光学成像实验、麻醉药、杂项用品(注射器、加热平台、外科手术 材料，免疫低下小鼠的隔离器，SAISR设计的多模式成像室 工作人员)和数据分析软件。还为动物方案准备、放射治疗提供了援助 多通道图像的安全审批、数据分析和演示以及联合配准。所有乐器 由SAISR工作人员进行维护和校准。与JCCC有长期联系的关键工作人员， SAISR和调查人员提供技术援助和实验指导及专业知识。在……里面 除了协助调查人员制定具体的实验方案外，SAISR还为 开发和翻译新仪器、探头和造影剂的调查人员，以及 协助生物分布、剂量学和毒理学研究。(另请参阅关于共享的第6.2.3节 历史上的资源、描述、基本特征)。 代表八个癌症中心计划地区的29名癌症中心成员利用 在本报告所述期间，小动物成像共享资源。这是一个持续的共享 资源。

The Small Animal Imaging Shared Resource (SAISR) was established as a JCCC Shared Resource in 2002, with a prototype microPET scanner, a microCT, a digital whole body autoradiograpy (DWBA) system and an optical imaging system. Twelve JCCC faculty formed the user base in 2002. During the past five years all initial SAISR instrumentation has been replaced; we currently have a dedicated imaging suite that houses a new microCT, two microPET instruments, a new cryostat and DWBA system, three bioluminescence/fluorescence optical imaging instruments and a Maestro spectral filtering fluorescence system. All instrumentation was obtained with institutional support. The SAISR has a dedicated vivarium for bngitudinal imaging studies. Our user base has grown to 44 faculty members who performed over 14,000 imaging experiments last year. JCCC members from seven Program Areas performed 86% of these studies. JCCC CCSG support for the SAISR is 14% of the SAISR operating budget. During 2008 the SAISR will move into a new 1500-sq. ft. imaging laboratory in the California NanoSystems Institute building. This facility will include a dedicated vivarium, procedure rooms, microPETs, microCT, bioluminescence, fluorescence and DWBA capabilities and adjacent space for a cyclotron dedicated to small animal imaging research and for radiochemistry facilities. This new physical facility is a tangible demonstration of institutional support for the SAISR in particular and the JCCC in general. The SAISR is "full service," providing didactic "classroom" instruction and training in imaging instrumentation and animal handling protocols, individual instruction, online instruction, standard operating procedures for imaging procedures, on-line remote scheduling for instrumentation, data storage and archiving, data retrieval and data processing, on-site data retrieval for staff consultation and assistance in data processing, all probes and contrast reagents for microPET, microCT and optical imaging experiments, anesthetics, miscellaneous supplies (syringes, heating platforms, surgical materials, isolators for immunocompromised mice, multimodality imaging chambers designed by SAISR staff) and software for data analysis. Assistance is also provided for animal protocol preparation, radiation safety approval, data analysis and presentation and co-registration of multimodality images. All instruments are maintained and calibrated by SAISR staff. Critical staff, who have a long association with the JCCC, the SAISR and the investigators, provide both technical assistance and experimental guidance and expertise. In addition to assisting investigators with specific experimental protocols, the SAISR provides support to the investigators in the development and translation of new instrumentation, probes and contrast agents, and assists with biodistribution, dosimetry and toxicology studies. (Please also see Section 6.2.3 on Shared Resources in the History, Description, Essential Characteristics). 29 Cancer Center members representing eight Cancer Center Program Areas utilized the services of the Small Animal Imaging Shared Resource during the reporting period. This is a continuing shared resource.