Research Base

学院研究基地 下文按重点领域简要介绍爱因斯坦研究基地。 这些领域代表了爱因斯坦研究工作的中心基础，并在这里简要强调，但由于页面的限制和我们的研究人员的广泛多样性，我们无法完全描述我们所有的研究工作。这些描述包括爱因斯坦糖尿病中心的教师和来自其他机构的中心成员（以粗体表示）。在任何情况下，我们的许多研究人员都有研究计划， 涵盖了几个不同的领域，但只有一个特定的领域与几个代表性的参考突出显示。 当前糖尿病中心成员的完整列表见第17页，随附CD提供了自上次提交以来与DRTC直接相关的DRTC研究者发表的完整列表。本信息涵盖了自2006年提交上一次竞争性更新以来，当前糖尿病中心研究者的生产力，以及一些相关的既往项目/出版物。请 请注意，这一短时间跨度主要反映了与糖尿病中心更新的典型五年周期相比的临时资助期。糖尿病中心教师的主要研究工作可以分为6个重叠和互动的重点领域，包括1型（T1 DM）和2型（T2 DM）糖尿病。这些研究涵盖了基本的分子机制，细胞功能，综合系统生理学，临床前，临床和社区健康管理研究。主要研究方向为：1）胰岛生物化学、生物学和免疫学; 2）信号转导; 3）碳水化合物和脂质代谢; 4）糖尿病并发症和分子遗传学; 5）临床试验; 6）健康和健康差异的行为、心理和环境决定因素。在下面的部分中，我们总结了这些一般研究领域的教师研究基地。重要的是，在这些领域中的几个领域，进行最先进的动物模型生理学研究，为复杂的人类研究提供范例，反之亦然。

Faculty Research Base A brief description of the Einstein research base is provided below and is presented by area of emphasis. These areas represent the central base of the Einstein research efforts and are briefly highlighted here, but due to page limitations and the extensive diversity of our research faculty we are unable to fully describe all our research efforts. These descriptions include both the Einstein Diabetes Center faculty and the Center members from other institutions (indicated in bold). In any case, many of our investigators have research programs that cover several distinct areas but only one particular area with a few representative references are highlighted. The full list of current Diabetes Center members is provided on page 17 and the accompanying CD provides a complete list of publications by DRTC investigators that are directly related to the DRTC since the previous submission. This information covers the productivity of current Diabetes Center investigators since the submission of the last competitive renewal in 2006, plus a few pertinent previous projects/publications. Please note that this short time span reflects mainly the period of interim funding in contrast to the typical five-year cycle of Diabetes Center renewals. The primary research efforts of the Diabetes Center faculty can be divided into 6 overiapping and interactive areas of emphasis that encompass both Type 1 (T1DM) and Type 2 (T2DM) diabetes. These investigations cover the spectrum from basic molecular mechanisms, cell function, integrative system physiology, pre-clinical, clinical and community based health delivery management research. The major research directions are 1) Islet Biochemistry, Biology, and Immunology; 2) Signal Transduction; 3) Carbohydrate and Lipid Metabolism; 4) Diabetic Complications and Molecular Genetics; 5) Clinical Trials; and 6) Behavioral, Psychosocial and Environmental Detemiinants of Health and Health Disparities. In the following section, we summarize the faculty research base in each of these general research areas. Importantly in several of these areas, state-of-the-art animal model physiological studies are conducted providing paradigms for sophisticated human investigation, and vice-versa.