Career Development Program

胰腺癌SPORE的职业发展计划（CDP）的目标是招募和培训转化胰腺癌研究的基础和临床研究人员。我们主要关注年轻的研究人员，他们在UMN，UAB，Morehouse医学院（MSM）或塔斯基吉大学（TU）的适当基础科学或临床部门担任讲师，助理教授或副教授。我们建议在一个经验丰富的导师团队的监督下，将其纳入正在进行的SPORE研究。获奖者将接触并参与SPORE的跨学科和翻译研究重点，并与来自所有四个机构的SPORE研究人员互动。不太常见的是，接受者可能是一个更高级别的个人，具有成功的研究记录，希望将他/她的职业道路改变为胰腺癌转化研究。 我们希望获奖者能够确定，开发和完成适当的研究项目，并寻求其他职业发展奖项和赠款支持，作为启动成功的独立研究职业生涯的过程的一部分，并通过这样做进一步扩大SPORE转化研究工作。 我们的总体战略是确定优秀的候选人，指派一名导师协助制定供CDP小组委员会审查的预提案，然后指派导师团队的其他成员（包括一名统计学家）帮助制定完整的提案。CDP小组委员会将审查完整的提案，以选择最终获奖者。导师团队将在获奖期间继续与获奖者合作。 我们建议每年颁发2个职业发展奖，资助额为50，000美元。每年100，000美元的年度预算来自UAB的SPORE预算（50，000美元）以及UMN机构资金 5万元/年。各机构的职业发展基金分别与各机构的联邦CDP基金合并（UAB基金和UMN基金）。我们从每个机构的单独资金库中为项目提供资金，但科学审查和资助决定由一个单一的联合SPORE委员会，CDP小组委员会做出。为塔斯基吉和莫尔豪斯资助的项目有分包合同，所有奖项都不允许间接费用。此外，75万美元的UAB机构资金将为UAB在胰腺癌生物学或免疫学领域招募新的胰腺癌孢子提供部分支持。 后一次招聘是为了加强UAB的胰腺癌研究人员，因为Vickers博士和Yamamoto博士离开UMN。同样，UMN已承诺100万美元用于招募两名实体肿瘤生物学家，这可能会进一步加强他们在胰腺癌方面的研究。 总的来说，我们用新的方法大大加强了CDP提案，并有力地解决了每一个发现的弱点。新方法侧重于UMN，UAB，MSM和TU，由UMN和UAB SPORE调查人员联合开发，特别包括生物统计核心及其协调委员会，其中包括来自UMN和UAB的教师统计学家。统计人员 特别是O博士。Dale威廉姆斯，Alan Cantor，Chap Le，Sreeletha Meleth和Sharina Person。 其中，威廉姆斯博士和人在预防医学部和UAB综合癌症中心（CCC）的MSM和TU的类似活动中具有相当丰富的经验，并有持续的职业生涯 与这两个机构共同开展发展活动，并定期参加与这两个机构的视频会议。 实施这一新方案的总体战略在正文图1中突出显示。其实质是，申请人将被征求和分配一个主要的导师谁将指导一个预先建议的发展;预先建议将被审查，以选择一个完整的建议。一个三人导师小组，包括一名统计员，将被指派帮助指导申请人制定一个完整的建议。导师团队将继续与被选中的申请人一起获得资助，并在整个奖项期间提供帮助。 我们有一个完整的补充导师，包括教师统计学家，这将是这个过程所需要的。

The goal of the Career Development Program (CDP) of the Pancreatic Cancer SPORE is to recruit and train basic and clinical investigators for translational pancreatic cancer research. We focus primarily on young investigators with a faculty appointment at the rank of Instructor, Assistant Professor, or Associate Professor in an appropriate basic science or clinical department at UMN, UAB, Morehouse School of Medicine (MSM) or Tuskegee University (TU). We propose to incorporate them into the ongoing SPORE research under the supervision of an experienced mentor team. Awardees will be exposed to and participate in the interdisciplinary and translational research emphasis of the SPORE and interact with SPORE investigators from all four institutions. Less commonly, the recipient may be an individual at a more senior level with a successful research record, who wishes to alter his/her career path to pancreatic cancer translational research. We expect the awardees to identify, develop and complete an appropriate research project and also to seek other career development awards and grant support as a part of the process of initiating a successful Independent research career and by so doing to further expand the SPORE translational research effort. Our overall strategy is to identify outstanding candidates, assign a mentor to assist with developing a preproposal for review by the CDP Subcommittee, and then assign the remainder of the mentor team, to include a statistician, to help with developing the full proposal. The full proposals will be reviewed by the CDP Subcommittee for selection of the final awardees. The mentor team would continue to work with the awardee for the duration ofthe award. We propose to award 2 Career Development awards/year with funding at $50,000/award. The annual budget of $100,000 per year is derived from the SPORE budget of UAB ($50,000) as well as UMN institutional funds of $50,000/year. The institutional career development funds are pooled with the individual federal CDP funds at each institution separately (UAB pool and UMN pool). We fund projects at each institution out of their individual pools, but scientific review and funding decisions are made by a single joint SPORE committee, the CDP Subcommittee. Projects funded for Tuskegee and Morehouse have subcontracts, and all awards do not allow indirect costs. In addition, UAB institutional funds of $750,000 will provide partial support for recruitment of a new Pancreatic Cancer SPORE recruit at UAB in the field of pancreatic cancer biology or immunology. This latter recruitment is to enhance the pancreatic cancer research faculty at UAB given the departure of Drs. Vickers and Yamamoto to UMN. Similarly, UMN has committed $1 million for the recruitment of two solid tumor biologists which may further strengthen their research in pancreatic cancer. Overall, we have strengthened the CDP proposal considerably with a new approach and have addressed strongly each ofthe identified weaknesses. The new approach focuses on UMN, UAB, MSM, and TU and was developed jointly by the UMN and UAB SPORE investigators and specifically included the Biostatistics Core and its Coordinating Committee containing faculty statisticians from both UMN and UAB. Statisticians specifically included were Drs. O. Dale Williams, Alan Cantor, Chap Le, Sreeletha Meleth and Sharina Person. Of these, Drs. Williams and Person have considerable experience with similar activities with MSM and TU in the Division of Preventive Medicine and the UAB Comprehensive Cancer Center (CCC) have ongoing career development activities with both institutions and participate in regular videoconferences with both. The overall strategy for implementing this new program is highlighted in Figure 1 in the text. The essence is that applicants will be solicited and assigned a primary mentor who will guide the development of a preproposal; pre-proposals will be reviewed for selection for a full proposal. A three member mentor team, to include a statistician, will be assigned to help guide the applicant in the development of a full proposal. The mentor team will remain with the applicants selected for funding and assist throughout the life of the award. We have a full complement of mentors, including faculty statisticians that will be needed for this process.