Gated Optical DetectorsDose Guided Radiotherapy

一家小型电子原型企业已同意协助开发一种 第二代探测器接口。这个新接口将是自包含的，但将 仍然提供计算机数据接口。这将是一个自我门控系统，具有4个检测 通道和所有信号处理将完全通过硬件执行。此外，本发明还 NRL正在开发新的纤维，这种纤维在剂量响应方面将更加均匀， 基于100微米光纤而不是当前的400微米模型。所得 系统将作为辐射剂量测定系统进行确认，并将用于 涉及小野和微野剂量测定的非常规临床和研究测量 用于兆伏和千伏的X射线和电子束。有两个额外的 后续项目：（1）一个三阶段项目，开发剂量导向探测器阵列， 放疗或DGR。第一阶段是开发一个阵列的纤维作为一个矩形或 并研究了螺旋网格在放射治疗过程中产生的剂量图和小剂量效应 器官或射束定位的变化。第二阶段是了解信号变化的含义 并且如果检测到则中断治疗 信号与参考值相差预定的容限。第三阶段是 将网格信号的变化动态地链接到辐射场的校正变化， 放射治疗的在线、动态剂量控制。(2)一个单独的项目， 基于胶片的OSL剂量计，作为用于剂量测量的照相胶片的替代品。 使用分散在具有粘合剂的膜基底上的研磨OSL玻璃的初步测量 是有希望的，但必须找到更好的方法来生产均匀的OSL颗粒， 尺寸一种可能的方法是采用掺入OSL分子链的纳米颗粒， 我们现正与一间学术机构合作，探讨这方面的可行性。

A small electronics prototyping business has agreed to assist in the development of a second generation detector interface. This new interface will be self contained, but will still provide a computer data interface. It will be a self-gated system with 4 detection channels and all signal processing will be performed completely via hardware. Additionally, new fibers are being developed by NRL that will be more uniform in dose response and will be based on a 100 micron optical fiber rather than the current 400 micron model. The resulting system will undergo validation as a radiation dosimetry system and will be employed for non-routine clinical and research measurements involving small field and micro-field dosimetry for both megavoltage and kilovoltage x-ray and electron beams . There are 2 additional follow-on projects: (1) A three phase project to develop a detector array for dose-guided radiotherapy, or DGR. Phase I is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. Phase II is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. Phase III is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments. (2) A separate project to develop a film-based OSL dosimeter as a replacement for photographic film for dosimetry measurements. Preliminary measurements using ground OSL glass dispersed on a film substrate with a binder were promising, but better methods must be found to produce OSL particles that are uniform in size. One possible approach is to employ nanoparticles incorporating OSL molecular chains, and we are currently partnering with an academic institution to explore this possibility.