Molecular Profiling of Pancreatic Cancer

在担任终身研究员职位后的六个月里，我一直致力于在实验室建立一个胰腺癌研究项目。我们已经启动了大规模的mRNA和microRNA （miRNA）表达分析，25个胰腺导管腺癌（PDAC）样本和配对的周围非肿瘤胰腺来自流行病学概况的患者和3个正常胰腺来自非癌症捐赠者，这些样本是通过nci -马里兰大学资源合同收集的。我们还从德国的合作者那里获得了一套40个PDAC样本。在我们的研究中，这两组样本被用作测试和验证队列，以确定该疾病的新生物标志物。我们目前正在准备一份方案和问卷，以启动大巴尔的摩地区胰腺癌的病例对照研究。

In last six months, after assuming the tenure track investigator position, I have been working on establishing a pancreatic cancer research program in the laboratory. We have initiated the large-scale mRNA and microRNA (miRNA) expression analysis of 25 pancreatic ductal adenocarcinoma (PDAC) samples and paired surrounding non-tumorous pancreas from the patients with epidemiological profile and 3 normal pancreas from non-cancer donors that have been collected through the NCI-University of Maryland Resource Contract. We also have obtained a set of 40 PDAC samples from collaborators in Germany. The two sets of samples are being used as test and validation cohorts in our studies to identify novel biomarkers for the disease. We are currently preparing a protocol and questionnaire to initiate the case-control study of pancreatic cancer in the greater Baltimore area.