医学放射和其他治疗药物的研究-猫眼课题宝

医学放射和其他治疗药物的研究

批准号：

7966613

负责人：

Amy Berrington

金额：

$545.29万

依托单位：

DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/7966613

关键词：

Adolescent Adult Age Allogenic American Medical Association Ataxia Telangiectasia Benign Body of uterus Bone Marrow Bone Marrow Transplantation Brain Brain Neoplasms Breast Bronchi Cancer Etiology Cancer Survivor Cardiac Catheterization Procedures Categories Central Nervous System Neoplasms Cervix Uteri Chest Child Childhood Classification Cohort Studies Collaborations Color Combined Modality Therapy Country Data Diagnosis Diagnostic Disease Dose Educational workshop Epidemiology Esophagus Etiology Evaluation Family member Female Genital Diseases Fluoroscopy France Gender General Population Genomics Genus Cola Health Hereditary Disease Hereditary Retinoblastoma Histologic Hodgkin Disease Hyperthyroidism I131 isotope Immune System Diseases Immunosuppression Incidence Individual Inherited International Iodine Ionizing radiation Late Effects Life Link Long-Term Survivors Lung Lymphoproliferative Disorders Malignant Childhood Neoplasm Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of esophagus Malignant neoplasm of lung Malignant neoplasm of pancreas Malignant neoplasm of testis Malignant neoplasm of thyroid Massachusetts Medical Medical Societies Meta-Analysis Monitor Monograph Nested Case-Control Study Operative Surgical Procedures Pancreas Patients Pattern Pediatric Neoplasm Pharmaceutical Preparations Physicians Pleura Population Population Study Procedures Publishing Radiation Radiation therapy Radiation-Induced Cancer Radio Radiometry Rectum Reporting Research Personnel Retinoblastoma Review Literature Risk Risk Factors SEER Program Salivary Glands Sampling Scanning Second Primary Cancers Skin Skin Cancer Solid Neoplasm Stomach Survivors T-Cell Depletion Technology Testis Therapeutic Therapeutic Agents Thyroid Gland Time Trachea Transplantation Treatment Protocols Tuberculosis Universities Update Whole-Body Irradiation Woman Work X-Ray Computed Tomography bone cancer risk chemotherapy childhood cancer survivor cohort comparison group conditioning early adolescence high risk irradiation malignant breast neoplasm malignant stomach neoplasm mortality neoplasm registry population based radiation effect radiologist response risk benefit ratio scoliosis soft tissue symposium

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中文摘要

翻译

<br视网膜母细胞瘤后继发癌症风险 视网膜母细胞瘤（RB）患者队列已扩大至1996年至2006年期间接受治疗的400名RB患者，以评估视网膜母细胞瘤新治疗后继发癌症的风险。第二种癌症的死亡率在遗传性RB患者中继续增加，但在非遗传性RB患者中没有增加。 共济失调-毛细血管扩张患者家庭成员的癌症风险 由NCI组织的国际研讨会与来自英国、法国和四个北欧国家的研究人员举行，讨论汇集数据调查共济失调-毛细血管扩张患者家庭成员的癌症发病率。当前正在对数据进行格式化，以便进行汇总分析。脊柱侧凸患者的癌症死亡率和发病率风险一项多中心回顾性队列研究对5,573名接受脊柱侧凸诊断x射线监测的妇女进行了研究，发现她们死于乳腺癌的可能性比一般人群的妇女高70%。目前正在对全因死亡率和癌症死亡率进行分析。 马萨诸塞州结核病患者的三个队列正在研究到2002年的病因特异性死亡率，包括癌症，与青春期和成年早期接受多次胸部x线检查的辐射暴露有关。总的来说，我们发现辐射剂量和肺癌风险之间几乎没有正相关的证据。这些结果发表在2008年6月,在维尔辐射与健康会议上,有限公司 <字体颜色= " # 990000 " > 新的恶性肿瘤癌症幸存者:SEER癌症登记处,1973 - 2000 < /字体> 专著发表描述新恶性肿瘤的风险,出现在200万多名癌症幸存者27年期间的1973年到2000年,从海军罪案调查处SEER程序使用数据。对50多个成人和18个儿童肿瘤的后续癌症风险进行了系统的检查，按性别、最初诊断癌症时的年龄、诊断后的时间以及某些癌症的最初治疗和组织学类型进行了检查。 儿童癌症幸存者中继发性脑癌、乳腺癌和甲状腺癌 继发性脑癌、乳腺癌、甲状腺、唾液腺、骨癌的巢式病例对照研究在14000多名5年儿童癌症幸存者的队列中，研究人员对儿童恶性肿瘤的放疗和化疗治疗与这些第二原发性恶性肿瘤风险之间的关系进行了研究。在第二原发性甲状腺癌、脑癌、乳腺癌、骨癌和软组织癌的研究中已经完成了详细的辐射剂量测定，皮肤癌的研究也在进行中。 儿科CT扫描 在过去的二十年中，计算机断层扫描（CT）的使用已经变得广泛。据估计，美国每年对儿童和青少年进行200万至300万次CT检查。放射流行病学分部与泰恩河畔纽卡斯尔大学的合作者合作，发起了一项流行病学队列研究，以评估儿童CT扫描与辐射暴露相关的潜在癌症风险。 甲状腺功能亢进诊断性和治疗性使用碘-131后的癌症风险 该分支正在评估几个研究人群中诊断性和治疗性使用碘-131后的癌症风险。美国35000名甲状腺功能亢进患者接受I-131、手术、抗甲状腺药物或联合治疗，癌症死亡率正在更新。目前正在更新1万名接受碘-131治疗的瑞典甲状腺功能亢进患者和6 000名未接受放射性碘治疗的甲状腺功能亢进患者的癌症发病率和死亡率。 对近15000名妇女进行良性妇科疾病放射治疗后的癌症死亡率进行更新，以评估实体瘤风险。 与5个从事介入手术的医师协会合作，正在进行一项癌症死亡率的研究。从美国医学协会获得了更多的数据，以增加需要评估的介入医生的数量，评估放射科医生的癌症死亡率，并提供一组医生的比较。对文献进行了回顾，以估计进行心导管手术的心脏病学家的辐射剂量。 <字体颜色= " # 990000 " > 辐射剂量反应和第二主胃癌,胰腺癌和食管 < /字体> 一项国际研究的三个高致命性胃肠道恶性肿瘤进行霍奇金淋巴瘤的癌症幸存者中,睾丸,乳腺癌和宫颈癌已报告以人群为基础的癌症登记。研究的主要目的是提供有关辐射剂量和胃癌、食管癌和胰腺癌的风险的新的定量信息；评价年龄和化疗可能的影响；并获得与辐射有关的胃肠道癌症的长期时间模式的新数据。此外，将收集现有的生物样本，以确定放射治疗引起的第二种癌症的基因组畸变模式。 虽然电离辐射是中枢神经系统肿瘤病因学中为数不多的确定的危险因素之一，但由于个体研究数据不足，许多辐射效应问题仍未解决。我们建议广泛汇集来自受辐射人群的数据，以便更准确地量化剂量-反应关系，并更有力地评估受辐射年龄的影响、受辐射后达到的年龄和时间的风险时间模式、性别和分次照射的影响。我们正在进行文献综述，以确定哪些研究可能符合合并并评估可行性。 骨髓移植后的癌症 全球24,011例接受同种异体骨髓移植治疗的患者正在接受评估，以评估与全身医疗照射（8-15 Gy）的晚期效应和严重免疫抑制相关的所有癌症风险增加。导致严重免疫功能障碍的治疗，如供体骨髓的t细胞耗损，与移植后淋巴增生性疾病的高风险有关。包含全身照射的调理方案与实体瘤风险增加有关，新发现表明长期幸存者患乳腺癌的风险增加。

英文摘要

Second Cancer Risks following Retinoblastoma The cohort of 1,600 Retinoblastoma (RB) patients has been expanded to include 400 RB patients treated between 1996 through 2006 in order to evaluate the risk of second cancers following newer treatments for RB. Mortality from second cancer continues to be increased in hereditary RB patients, but not in patients with the non-hereditary form. Cancer Risks in Family Members of Ataxia-Telangiectasia Patients An international workshop organized by NCI was held with investigators from the UK, France and four Nordic countries to discuss pooling data to investigate cancer incidence in family members of ataxia-telangiectasia patients. Data are currently being formatted for pooled analyses. Cancer Mortality and Incidence Risks in Patients with Scoliosis A multi-center retrospective cohort study of 5,573 women who were monitored with diagnostic x-rays for their scoliosis found that they were 70% more likely to die from breast cancer than women in the general population. Analyses of all cause and cancer mortality are currently underway. Cancer Mortality following Multiple Chest Fluoroscopies for Tuberculosis Three cohorts of Massachusetts tuberculosis patients are being studied for cause-specific mortality through 2002, including cancer, in relation to radiation exposure from multiple chest fluorscopies received during adolescence and early adult life. Overall, we found little evidence of positive association between radiation dose and risk of lung cancer. These results were presented at June 2008, Radiation and Health Conference in Vail, Co. New Malignancies Among Cancer Survivors: SEER Cancer Registries, 1973-2000 A monograph was published describing the risk of new malignancies that have arisen among more than 2 million cancer survivors for the 27-year period 1973 to 2000, utilizing data from NCIs SEER Program. The risks of subsequent cancers are systematically examined for more than 50 adult and 18 childhood tumors by gender, age at diagnosis of the initial cancer, and time since diagnosis, as well as the initial treatment and histologic type of certain cancers. Secondary Cancers of the Brain, Breast, and Thyroid Among Childhood Cancer Survivors Nested case-control studies of second primary cancers of the brain, breast, thyroid gland, salivary gland, bone, soft tissue and skin following an initial childhood cancer are being conducted within a cohort of more than 14,000 5-year survivors of childhood cancer to evaluate the relationship between radiation and chemotherapy treatment of childhood malignancies and risk of these second primary malignancies. Detailed radiation dosimetry was completed for the studies of second primary thyroid, brain, breast, bone and soft tissue cancer, and is in progress for the skin cancer study. Pediatric CT Scans Over the last two decades, the use of computed tomography (CT) scans has become widespread. It is estimated that 2-3 million CTs are performed annually on children and adolescents in the U.S. Working with collaborators from the University of Newcastle on Tyne, the Radiation Epidemiology Branch initiated an epidemiological cohort study to evaluate the potential risk of cancer associated with radiation exposure from pediatric CT scans. Cancer Risks following Use of Diagnostic and Therapeutic I-131 for Hyperthyroidism The Branch is evaluating the risk of cancer following diagnostic and therapeutic Iodine-131 in several study populations. Cancer mortality is being updated for a US cohort of 35,000 hyperthyroid patients treated with I-131, surgery, anti-thyroid drugs or combination therapy. Cancer incidence and mortality are currently being updated in 10,000 Swedish hyperthyroid patients treated with I-131 and a comparison group of 6,000 hyperthyroid patients who were not treated with radio-iodine. Cancer Mortality Among Women Treated with Radiotherapy for Benign Gynecologic Disease Cancer mortality following radiation treatment for benign gynecologic disease in a cohort of nearly 15,000 women is being updated to evaluate solid tumor risk. Radiation Risks from Interventional Fluoroscopy In collaboration with 5 medical societies of physicians who perform interventional procedures, a study of cancer mortality is being conducted. Additional data have been obtained from the American Medical Association to increase the number of interventional physicians to be evaluated, evaluate cancer mortality in radiologists, and provide a comparison group of physicians. A review of the literature was conducted to estimate the radiation doses to cardiologists performing cardiac catheterization procedures. Radiation Dose-Response and Second Primary Cancers of the Stomach, Pancreas and Esophagus An international study of three highly lethal GI malignancies is being conducted among cancer survivors of Hodgkin lymphoma, and testis, breast and cervical cancer that have been reported to population-based cancer registries. The major study objectives are to provide new quantitative information on radiation dose and the subsequent risk of stomach cancer, esophageal cancer, and pancreatic cancer; to evaluate the possible influence of age and chemotherapy; and to generate new data on the long-term temporal patterns of radiation-related GI cancers. In addition, available biologic samples will be collected to identify patterns of genomic aberrations in radiotherapy-induced second cancers. Radiation & Brain tumors: A pooled analysis While ionizing radiation is one of the few well-established risk factors in the etiology of CNS tumors, many issues of radiation effects remain unresolved due to insufficient data in individual studies. We suggest a broad pooling of data from radiation exposed populations aiming at more accurate quantification of the dose-response relationship and stronger power to assess the influence of age at exposure, temporal patterns of risk in terms of attained age and time since exposure, the effects of gender and fractionated exposures. We are conducting a literature review of what studies might be eligible for the pooling and assessing feasibility. Cancer Following Bone Marrow Transplantation 24,011 patients worldwide, treated with allogeneic bone marrow transplants are being evaluated for increased risk of all cancer related to the late effects of total-body medical irradiation (8-15 Gy), and severe immunosuppression. Treatments resulting in severe immune dysfunction, such as T-cell depletion of the donor bone marrow, were linked to high risks of post-transplant lymphoproliferative disorders. Conditioning regimens containing total body irradiation were associated with increased risks of solid tumors, with new findings showing an increased risk of breast cancer among long-term survivors.

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