Effect of Diet on Vascular Disease: Study of African American & Caucasian Women

在本研究中，我们将招募48名女性（24名非洲裔美国人和24名白人女性）。为了尽量减少年龄和更年期的影响，我们正在招募18至49岁的女性。 该研究将涉及到NIH临床中心的几次门诊访视。第一次访视将是一次筛选，以确定合格性。在第二次访视时，将进行一项测试以测量胰岛素抵抗。这种测试被称为频繁采样静脉葡萄糖耐量试验。第三次访视将针对试验餐。 在餐前和餐后2、4和6小时，将抽取血液并测量血管功能。通过测量血压，然后用超声波测量手臂的血流量来确定血管功能。饮食的个体差异可能会影响试验餐当天的血管研究结果。因此，在试验餐前7天，NIH临床中心将以托盘或盒装餐的形式向每位受试者提供所有膳食。这些膳食将包括典型的美国饮食，33%的脂肪，15%的蛋白质和52%的碳水化合物。 在设计这些膳食时，营养师将考虑个人的食物偏好。26名女性（13名非洲裔美国人和13名高加索人）现已完成研究。目前正在对已收集的数据进行登记和分析。

For this study we will enroll 48 women (24 African American and 24 Caucasian women). To minimize the effect of age and menopause, we are enrolling women between the ages of 18 and 49 years. The study will involve several outpatient visits to the NIH Clinical Center. The first visit will be a screening to determine eligibility. At the second visit a test will be performed to measure insulin resistance. This test is called a frequently sampled intravenous glucose tolerance test. The third visit will be for the test meal. Before and at 2, 4 and 6 hours after the meal, blood will be drawn and vascular function measured. Vascular function is determined by taking blood pressure and then measuring blood flow in the arm with ultrasound. It is possible that individual differences in diet could affect the results of the vascular study on the day of the test meal. Therefore for 7 days prior to the test meal, the NIH Clinical Center will provide to each participant all their meals in the form of either trays or meals in a box. These meals will consist of the typical American diet and be 33% fat, 15% protein and 52% carbohydrate. In designing these meals, the dietician will take into account individual food preferences. Twenty-six women (13 African American and 13 Caucasian) have now completed the study. Enrollment and analyses of data already collected is underway.