Genetic Variation in Amphetamine Response

描述（由申请人提供）：此申请申请为Ajna Hamidovic博士提供两年的博士后支持，以扩展她在人类精神药理学研究方面的培训。具体来说，她建议在美国国立卫生研究院资助的一项正在进行的研究项目（DA021336; PI Abraham Palmer; Co Investigator Harriet de Wit）的背景下，获得研究急性药物反应的遗传基础的培训。这项培训申请的总体目标是为Hamidovic博士提供作为药物滥用研究领域的研究科学家开展独立职业所需的工具。具体而言，候选人将接受有关进行具有遗传变量的人类精神药理学研究的各个方面的培训。她的培训将包括课程、研讨会和一对一的阅读课程，以提供相关文献的全面知识，以及与这类研究相关的理论和方法问题。她将学习开展研究的各个方面，包括设计、招聘、筛选、测试、监督助理、管理和分析数据，以及准备发表和演示结果。该研究的具体目的是在三个领域调查健康志愿者对达非他明（0-20毫克）急性反应变异的遗传来源：i)主观或情绪改变效应，ii)药物对冲动行为的影响，以及iii)药物对其他认知测量的影响。受试者将对与这些测量方法相关的几个基因的多态性进行基因分型。美国国立卫生研究院（nih）资助的这项培训项目的基础是研究这种药物改变情绪的效果，但哈米多维奇博士将把这项研究扩展到研究这种药物对冲动行为和认知测量的影响。

DESCRIPTION (provided by applicant): This NRSA F32 application requests two years of post doctoral support for Dr. Ajna Hamidovic to extend her training in research in human psychopharmacology. Specifically, she proposes to obtain training to study the genetic basis of responses to acute drugs, in the context of an ongoing NIH-funded research project (DA021336; PI Abraham Palmer; Co Investigator Harriet de Wit). The broad goal of this training application is to provide Dr. Hamidovic with the tools needed to launch an independent career as a research scientist in drug abuse research. Specifically, the candidate will receive training in all aspects of conducting a human psychopharmacological study with genetic variables. Her training will include courses, seminars and one-qnone reading sessions to provide a comprehensive knowledge of the relevant literature, as well as both the theoretical and methodological issues related to this type of research. She will learn all aspects of conducting the research including design, recruitment, screening, testing, supervision of assistants, management and analysis of data, and preparing results for publication and presentations. The specific aims of the research study are to investigate the genetic sources of variation in acute responses to damphetamine (0-20 mg) in healthy volunteers, in three domains: i) subjective or mood altering effects, ii) effects of the drug on impulsive behavior, and iii) effects of the drug on other measures of cognition. Subjects will be genotyped for polymorphisms in several genes that have been associated with each of these measures. The NIH-funded grant upon which this training project is based was designed to investigate the mood-altering effects, but Dr. Hamidovic will extend this investigation to also examine the effects of the drug on impulsive behaviors and measures of cognition. PUBLIC HEALTH RELEVANCE: The relevance of this study to public health is new information about the genetic variability in the quality of magnitide of subjective and behavioral responses to commonly abused drugs which may help researchers understand why some individuals are vulnerable to, or protected from, drug addiction.