Low-Dose MRI-Compatible Molecular Breast Imaging Device

描述（由申请人提供）：使用肿瘤导向放射性示踪剂的分子乳腺成像已被证明在乳腺癌检测中具有高度准确性，特别是对于浸润前病变。去除浸润前病变是浸润性癌症预防的理想目标。为了进行癌症预防研究，我们必须在不牺牲空间和能量分辨率的情况下，显著降低与分子乳腺成像相关的辐射剂量，并实现MRI兼容性。MRI与配准的兼容性可能会增加检测小浸润性癌症的灵敏度，并提高整体诊断准确性。 公共卫生相关性：使用我们提出的系统将产生经济效益，导致从检测（和治疗）的前浸润性乳腺癌，以避免更昂贵的治疗患者的潜在转移性浸润性乳腺癌。预防浸润性乳腺癌有望延长大量高危女性的生命，减少焦虑。

DESCRIPTION (provided by applicant): Molecular breast imaging with tumor-seeking radiotracers has been shown to be highly accurate in the detection of breast cancer, particularly for pre-invasive lesion. Removal of pre-invasive lesions represents an ideal target for invasive cancer prevention. In order to conduct cancer prevention studies, we must significantly reduce the radiation dose associated with molecular breast imaging and implement MRI compatibility, without sacrificing spatial and energy resolution. MRI compatibility with co-registration would likely increase sensitivity for detecting small invasive cancers and improve overall diagnostic accuracy. PUBLIC HEALTH RELEVANCE: Use of our proposed system will yield economic benefits that result from detection (and treatment) of pre-invasive breast cancers, so as to avoid the more expensive treatment of patients with potentially metastatic invasive breast cancer. Prevention of invasive breast cancer is expected to prolong life and reduce anxiety for a large number of high-risk women.