IBIC: Integrated Brain Imaging Center for the University of Washington

描述(由申请者提供)：该项目的目标是加速发现，并在华盛顿大学(UW)建立一个跨认知神经科学、人类神经成像和医学的多学科互动的新计划。该项目利用综合脑成像中心的基础设施，与现有的现有中心和小组合作，这些中心和小组的科学计划可以立即利用新的系统神经成像方法调查神经退行性疾病、脑老化、癫痫和瘫痪康复方面的基本和翻译问题。威斯康星大学是首屈一指的生物医学研究机构，在使用成像来阐明疾病的生物机制和生物标记物以及进行转译研究方面具有特别强大的机构背景。这项提案的主题是应用新兴系统神经成像方法来解决神经系统疾病病理生理学和关键翻译环境中的关键基本问题。一个项目集中于系统神经成像和磁共振波谱的新用途，以了解退行性疾病(阿尔茨海默病、帕金森病)的机制。一个目标是了解和检测阿尔茨海默病默认模式网络的早期脆弱性。在这项工作中，我们将使用两个受试组：特征良好的轻度认知障碍，通常反映早期阿尔茨海默病，以及根据中年和老年的认知轨迹严格分层的老年个体。第二个目标是了解帕金森病的认知障碍，这些障碍主要出现在上升系统的干扰环境中。第三个目标是了解影响癫痫手术后语言和其他认知障碍预后的因素。第二个集群项目群由华盛顿大学在人类神经生理学、电生理学和感觉运动工程方面的杰出专业知识推动，重点是将成像与电生理学相结合，以了解临床相关大型系统(默认模式网络、背部注意网络)的神经生理学动力学，并改善瘫痪康复的脑机接口。对于每一次协作，我们都会提出一个初步的高影响力研究和未来方向。 与公共卫生相关：该项目将在华盛顿大学发展新的协作科学团队，与综合脑成像中心合作，并将新的成像方法应用于退行性痴呆、脑老化、癫痫和瘫痪的康复。其中一组项目将调查早期阿尔茨海默病的生物学基础，帕金森病的注意力和注意力障碍，以及癫痫手术中的语言问题。第二组项目将使用脑电和成像来了解大脑系统中的信号，以及如何提取信号来控制脑机接口。)

DESCRIPTION (provided by applicant): The objective of the project is to accelerate discovery and a new program for multidisciplinary interaction across cognitive neuroscience, human neuroimaging and medicine at the University of Washington (UW). The project uses the infrastructure of the Integrated Brain Imaging Center to partner with existing established Centers and groups whose scientific programs can immediately investigate basic and translational questions in neurodegenerative disease, brain aging, epilepsy, and rehabilitation of paralysis with new systems neuroimaging approaches. The UW is a premier biomedical research institution and a particularly strong institutional setting for using imaging to elucidate biological mechanisms and biomarkers of disease, and for conducting translational studies. The theme of this proposal is the application of emerging systems neuroimaging approaches to key basic problems in neurologic disease pathophysiology, and key translational settings. One project cluster centers around novel uses of systems neuroimaging and MR spectroscopy to understand mechanisms in degenerative disease (Alzheimer disease, Parkinson disease). One goal is to understand and detect the early vulnerability of the default mode network in Alzheimer disease. For this work, we will use two subject groups: well characterized mild cognitive impairment, which often reflects incipient Alzheimer disease, and aging individuals who have been rigorously stratified with respect to their cognitive trajectories in midlife and old age. A second goal is to understand cognitive impairments in Parkinson disease, which arise in the setting of disturbances primarily in ascending systems. A third goal is understanding factors governing prognosis for language and other cognitive impairments after epilepsy surgery. A second cluster project cluster is driven by outstanding UW expertise in human neurophysiology, electrophysiology and sensorimotor engineering, and focuses on integration of imaging with electrophysiology to understand the neurophysiologic dynamics of clinically relevant large scale systems (default mode network, dorsal attentional network), and to improve brain-computer interfaces for rehabilitation of paralysis. For each collaboration we propose an initial high impact study and future directions. PUBLIC HEALTH RELEVANCE: This project will develop new collaborative scientific teams at the University of Washington to work in partnership with the Integrated Brain Imaging Center and apply new imaging methods to degenerative dementia, brain aging, epilepsy, and rehabilitation of paralysis. One cluster of projects will investigate the biological basis of early Alzheimer disease, disorders of attention and concentration in Parkinson disease, and language problems in epilepsy surgery. A second cluster of projects will used EEG and imaging to understand signaling in brain systems and how to extract signals for controlling brain-computer interfaces. )