Upgrade of GE 3.0T SIGNA MRI Scanner for Enhanced Neuroimaging

描述（由申请人提供）：此共享仪器提案是将现有的专用研究通用电气3T MRI扫描仪从版本11B升级到版本15。该扫描仪于2005年安装，使用的资金来自NCRR的高端仪器奖（S10 RR017215）。威斯康星医学院（MCW）生物物理学教授James S. Hyde博士是该提案的PI，并再次担任该提案的PI。生物物理系位于MCW校园研究大楼的一层，扫描仪安装在专门建造的一层楼里，与该大楼相连，与部门楼层在同一层，进出非常方便。这座单层建筑的建造资金由MCW提供，表明该机构对成像研究的大力支持。这台扫描仪专门用于神经成像。虽然MCW校园附近有许多医院和医疗设施，但该扫描仪的临床使用没有收费服务。它完全致力于研究。来自MCW众多部门的研究人员，包括基础科学和临床，都使用该设施。这次升级对用户群体有四个主要好处：(1)大大改善了梯度驱动程序；(2)先进的扩散张量成像技术；(3)将8通道头线圈、8通道接收器和成像软件升级为16通道，用于SENSE成像；(4)将控制接口升级到当前水平。关于益处(4)，该扫描仪将成为MCW临床转化科学研究所（CTSI）成像核心的一个关键方面，并将被MCW、马奎特大学和威斯康星大学密尔沃基分校的跨大学边界的研究人员使用。它被认为是重要的，控制界面是最新的项目，旨在早期阶段的转化研究。从9个主要资助用户描述了10个项目。此外，还以表格形式总结了14个次要用户的项目。MCW的MRI生物物理研究团队在技术进步方面有着悠久的历史，包括表面线圈的早期论文（20世纪80年代），使用60厘米布鲁克扫描仪进行的早期人体研究（20世纪90年代），第一篇关于功能磁共振成像的论文（1992年），功能连接MRI （fcMRI）的发现（1995年），以及实时功能磁共振成像的最早报告。同样，MCW神经科学团队长期以来一直处于语音和语言处理成像研究的前沿，癫痫的术前绘图，视觉和视觉注意，运动控制和定时，涉及药物成瘾的神经系统，脑肿瘤成像和阿尔茨海默病的早期检测。本提案中描述的项目涵盖了广泛的成像科学、神经科学和转化研究，这些研究都是从这些开创性的贡献中发展而来的。此次升级将加强集中MRI资源的共享利用，丰富正在进行的研究，促进新的研究方向，营造合作和互动的研究环境，并促进神经科学的多学科研究。

DESCRIPTION (provided by applicant): This shared instrumentation proposal is for upgrade of an existing research-dedicated General Electric 3T MRI scanner from Version 11B to Version 15. This scanner was installed in 2005 using funds from a high-end instrumentation award from NCRR (S10 RR017215). James S. Hyde, Ph.D., Professor of Biophysics at the Medical College of Wisconsin (MCW) was PI of that proposal and serves again as PI of this proposal. The Department of Biophysics occupies the ground floor of a research tower on the MCW campus, and the scanner was installed in a purpose-built, one-story building attached to the tower at the same level as the departmental floor, providing very convenient access. Funds for construction of this one-story building were provided by MCW, indicating substantial support of imaging research by the institution. The scanner is used exclusively for Neuroimaging. Although there are numerous hospitals and medical facilities immediately adjacent to the MCW campus, there is no clinical fee-for-service usage of this scanner. It is dedicated totally to research. Investigators from numerous departments of MCW, both basic science and clinical, make use of the facility. This upgrade has four major benefits for the user community: (1) greatly improved gradient drivers; (2) state-of- the-art diffusion tensor imaging; (3) upgrade of the eight-channel head coil, eight-channel receiver, and image- formation software to 16 channels for SENSE imaging; and (4) upgrade of the control interface to current levels. With respect to benefit (4), this scanner will be a key aspect of the Clinical Translational Science Institute (CTSI) Imaging Core at MCW and will be employed by investigators across university boundaries at MCW, Marquette University, and the University of Wisconsin-Milwaukee. It is felt to be important that the control interface be up to date for projects intended for early stage translational research. Ten projects are described from nine major funded users. In addition, projects are summarized in tabular form for 14 minor users. The MRI Biophysics research team at MCW has a long history of pioneering technological advances, including very early papers on surface coils (1980s), early human studies at 3T using a 60-cm Bruker scanner that was purchased from a shared instrumentation award (1990s), the first paper to be published on fMRI (1992), the discovery of functional connectivity MRI (fcMRI) (1995), and the earliest report of real-time fMRI. Similarly, the MCW Neuroscience team has long been at the forefront of imaging research on speech and language processing, presurgical mapping in epilepsy, vision and visual attention, motor control and timing, neural systems involved in drug addiction, brain tumor imaging, and early detection of Alzheimer's disease. Projects described in this proposal cover the wide range of imaging science, neuroscience, and translational research that has evolved from these pioneering contributions. The upgrade will enhance the shared use of the centralized MRI resources, enrich ongoing research, promote new research directions, foster a cooperative and interactive research environment, and stimulate multidisciplinary approaches to neuroscience. PUBLIC HEALTH RELEVANCE: Functional magnetic resonance imaging (fMRI) continues to be a rapidly evolving technique that continues to reveal new information about both the healthy and the diseased human brain. This shared instrumentation proposal to upgrade an existing research-dedicated 3 Tesla MRI scanner will have many advantages for the investigators who use the instrument, of which the most important is higher sensitivity using 16 channels of data acquired from the brain simultaneously-so-called SENSE imaging. The applicants are pioneers in the development and application of fMRI.