High Resolution Imaging System

描述(由申请人提供)：我们申请资金从Visualsonics购买Vevo 2100高分辨率超声成像系统。生物医学成像已经成为实验动物模型系统表型分析的重要工具，提供关于正常和异常发育、疾病进展和消退以及治疗反应的信息。在现有的众多成像方式中，超声的独特之处在于：(1)操作相对简单，(2)提供高度准确和可重复性的结果，(3)可在活体上以非侵入性方式进行，(4)可广泛应用于各种发育阶段，(5)提供高空间和时间分辨率，适于对心脏和血管系统等动态结构进行成像，(6)可进行连续测量，从而可随时间对发育过程以及疾病进展和/或退化进行评估。十多年来，纽约大学医学院的研究人员一直是高分辨率超声成像领域的领导者，特别是在小鼠身上，基因工程小鼠模型被用来增加我们对正常和病理生物学过程的理解。这些研究在心血管、神经和癌症生物学领域取得了特别丰硕的成果。最新一代的超声成像设备提供了显著增强的空间和时间分辨率，它在纽约大学医学院的供应将增强NIH资助的大量研究人员的研究计划。我们还预计，这种设备的上市将吸引可能受益于先进成像的新用户。通过加强我们对新知识的追求，我们将更有效地为NIH的使命做出贡献，即做出改善健康和拯救生命的重要医学发现。 与公共卫生相关：生物医学成像已成为可视化正常和异常发育过程、疾病进展和消退以及治疗反应的重要工具。这一共享仪器项目将使我们能够获得最先进的超声成像系统，该系统可以为小到发育中的小鼠的实验动物提供无与伦比的高质量图像。通过这些图像，我们将深入了解人类发展和疾病的生物机制，最终改善健康和拯救生命。

DESCRIPTION (provided by applicant): We request funds to purchase the Vevo 2100 high resolution ultrasound imaging system from Visualsonics. Biomedical imaging has emerged as an essential tool in the phenotypic analysis of experimental animal model systems, providing information on normal and abnormal development, disease progression and regression, as well as response to treatment. Among the large array of imaging modalities currently available, ultrasound is unique in that studies are (1) relatively simple to perform, (2) provide highly accurate and reproducible results, (3) can be performed non-invasively on living organisms, (4) can be applied to a broad range of developmental stages, (5) provide high spatial and temporal resolution suitable for imaging of dynamic structures such as the heart and vasculature, and (6) allow for serial measurements, such that developmental processes as well as disease progression and/or regression can be assessed over time. For over a decade, investigators at NYU School of Medicine have been leaders in the field of high resolution ultrasound imaging, particularly in the mouse, where genetically engineered murine models have been used to increase our understanding of normal and pathologic biological processes. These studies have been particularly fruitful in the areas of cardiovascular, neurologic and cancer biology. The most recent generation of ultrasound imaging equipment provides significantly enhanced spatial and temporal resolution and its availability at NYU School of Medicine will enhance the research programs of a large cadre of NIH-funded investigators. We also anticipate that the availability of this equipment will attract new users who may benefit from advanced imaging. By enhancing our pursuit of new knowledge we will more effectively contribute to the NIH mission of making important medical discoveries that improve health and save lives. PUBLIC HEALTH RELEVANCE: Biomedical imaging has emerged as an essential tool to visualize normal and abnormal developmental processes, disease progression and regression, as well as response to treatment. This shared instrumentation project will enable us to obtain a state of the art ultrasound imaging system that provides unparalleled high quality images of experimental animals as small as the developing mouse. Through these images, we will gain insight into the biological mechanisms responsible for human development and disease, ultimately improving health and saving lives.