Molecular Mechanisms of Immune Tolerance

描述(由申请人提供)：我们请求支持一个博士后培训计划，重点是免疫耐受和自身免疫的分子机制。这一应用紧随免疫学综合系的发展而来，该系的教职主要集中在B和T细胞的发展、抗原识别、谱系的开发、通过编辑、删除和无能而沉默，以及理解自身免疫。免疫学综合系由来自三个机构的56名教员(初级和中级)组成：国家犹太医学和研究中心(NJMRC)、芭芭拉·戴维斯儿童糖尿病中心(BDC)和科罗拉多大学丹佛分校和健康科学中心(UCDHSC)。自1999年成立以来，21名培训教师中有近一半已被招聘到该部门，所有培训教师都得到了NIH R0I补助金的支持，他们是首席研究员。我们要求为4名研究员提供津贴支持，他们将在自己选择的实验室接受培训。这些研究员将参加定期安排的期刊俱乐部、正在进行的研究研讨会、正式研讨会和课程，例如关于科学伦理和生存技能的研讨会和课程，他们的进展将由培训监督委员会(TOC)监督。学员的任期为一年，只有在TOC认为他们取得重大进展的情况下，才会重新任命他们。我们的目标是为研究员提供关于免疫耐受和自身免疫小鼠模型的全面知识，以及对临床自身免疫的充分了解，以使他们能够为研究翻译发展富有成效的临床协作关系。该计划的负责人是John Cambier博士，Ida和Cecil Green教授，免疫学综合系主任。坎比尔博士是B细胞信号、激活和无能方面的专家，他已经培训了60多名研究生和博士后研究员。培训计划拥有一流的研究设施。教职员工在培训和研究方面都是互动的。虽然丹佛免疫学社区培养博士后和博士后研究员已经有30多年了，但免疫学综合系的成立和新教师的聘用提供了强大的团结影响力，并为我们的教育和研究活动注入了新的兴奋和活力。这个培训项目是这种活力的中心焦点。

DESCRIPTION (provided by applicant): We request support for a postdoctoral training program focused on molecular mechanisms of immunologic tolerance and autoimmunity. This application comes on the heels of development of an Integrated Department of Immunology whose faculty is strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and understanding autoimmunity. The Integrated Department of Immunology is comprised of 56 faculty (primary and secondary) from three institutions: the National Jewish Medical and Research Center (NJMRC), The Barbara Davis Center for Childhood Diabetes (BDC) and The University of Colorado at Denver and Health Sciences Center (UCDHSC). Nearly half of the 21 training faculty have been recruited to the Department since its inception in 1999, and all training faculty are supported by NIH R0I grants on which they are Principal Investigator. We request stipend support for 4 fellows who will train in laboratories of their choosing. The fellows will participate in regularly scheduled journal clubs, research in progress seminars, formal seminars and courses, e.g., on ethics and survival skills in science, and their progress will be monitored by a training oversight committee (TOC). Trainees will be appointed for one year and reappointed only if they are judged by the TOC to be making significant progress. Our goal is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. The Program Director is Dr. John Cambier, Ida and Cecil Green Professor and Chairman of the Integrated Department of Immunology. Dr. Cambier is an expert in B cell signaling, activation and anergy, and has trained in excess of 60 graduate students and postdoctoral fellows. The training program has available superb research facilities. and the faculty are interactive in both training and research. Although the Denver immunology community has been training pre- and postdoctoral fellows for over 30 years, the formation of the Integrated Department of Immunology and hiring of new faculty has provided a strongly uniting influence, and injected new excitement and vitality into our educational and research activities. This training program is a central focus of that vitality.