Multidisciplinary Fellowship in Dementia Research

描述(由申请人提供)：这是加州大学(UCSF)行为神经学和神经退行性疾病多学科博士后培训项目的首次竞争性续签申请，该项目由Bruce Miller医学博士指导。该项目的目标是培养未来行为神经学研究的领导者。该项目目前已进入资助的第四个年头。它吸引了一群不同的、非常有成就的申请者，并资助了七名神经科医生的培训，他们来自著名的神经学住院医生。其中四名研究员已经完成了我们的项目，并进入了稳定的学术职位，在那里他们在研究、教育和临床护理方面追求卓越，另外三名研究员正在继续他们的培训。拟议的赠款将继续为将多样化的临床经验与教学相结合的两年期奖学金提供支持。第一年的临床经验将包括在行为神经学诊所、阿尔茨海默病研究中心、评估FTD和相关疾病的计划项目赠款、加州大学旧金山分校的退行性痴呆临床试验计划以及快速进展性痴呆症计划。我们的教员将通过专门为该项目设计的新课程来提供教学。这些讲座涉及与行为神经学和神经退行性疾病相关的关键主题，包括临床表现、基础生物学、神经成像、数据管理和分析、研究设计以及大脑行为对道德行为的影响。这些课程将通过互联网作为正式课程提供，供其他培训方案使用。在第二年，研究员将把重点转移到基础研究上，与特定的研究导师合作，花更少的时间从事临床工作。可用的导师名单包括在与痴呆症相关的各种学科工作的有成就的研究人员，包括认知和行为评估、神经成像、流行病学和板凳研究。该计划每年将支持三名新的研究员，这些奖学金将向神经学家、精神病学家、老年病学家或神经心理学家开放。 公共卫生相关性：痴呆症研究的快速步伐表明，未来对痴呆症研究人员的需求将越来越大。这些研究人员将需要擅长早期和准确的诊断，熟悉临床研究的设计和后勤，并熟练地处理伦理问题。拟议的计划将把所有这些要素纳入未来痴呆症研究人员的培训。

DESCRIPTION (provided by applicant): This is the first competitive renewal application for the University of California (UCSF) multidisciplinary post- doctoral training program in Behavioral Neurology and neurodegenerative disease, directed by Bruce Miller, M.D. The goal of the program is to train future leaders in Behavioral Neurology research. The program is currently in its fourth year of funding. It has attracted a diverse and highly accomplished group of applicants and funded the training of seven neurologists, who came from prestigious Neurology residencies. Four of the fellows have completed our program and have moved into stable academic positions where they pursue excellence in research, education and clinical care, while three others are continuing their training. The proposed grant would provide continued support for two-year fellowships that will combine a diverse set of clinical experiences with didactics. First year clinical experience will include time in the Behavioral Neurology clinic, the Alzheimer's Disease Research Center, the program project grant for assessment of FTD and related disorders, the UCSF clinical trials program for degenerative dementias, and the rapidly progressive dementia program. Didactics will be provided through new courses designed specifically for this program by our faculty. The lectures tackle key topics relevant to Behavioral Neurology and neurodegenerative disease, including clinical presentation, basic biology, neuroimaging, data management and analysis, study design, and brain-behavior influences upon ethical behavior. These courses will be made available via the Internet as a formal curriculum for use by other training programs. During the second year, fellows will shift focus towards basic research, working with a specific research mentor, and spend less time with clinical duties. The list of available mentors includes accomplished researchers working in a variety of disciplines related to dementia, including cognitive and behavioral assessment, neuroimaging, and epidemiology and bench research. The program will support three new fellows per year for fellowships that will be open to neurologists, psychiatrists, geriatricians or neuropsychologists. PUBLIC HEALTH RELEVANCE: The rapid pace of dementia research suggests that there will be an increasing need for dementia researchers in the future. These investigators will need to be adept at early and accurate diagnosis, familiar with the design and logistics of clinical studies, and comfortable dealing with ethical issues. The proposed program will incorporate all these elements into the training of future dementia researchers.