Motion Artifact Reduced SDOCT of the Anterior Segment

描述(由申请人提供)：在基于角膜的外科干预中，准确的角膜定量成像对于可预测的结果至关重要。虽然长期以来，基于反射的角膜地形图用于评估角膜曲率和屈光度的标准是不够的，但在一个手术操作角膜形状是例行公事的时代，并破坏了反射地形图的基础。激光屈光手术是一种特殊的角膜干预措施，它揭示了目前在测量角膜方面的不足。在美国，超过700万人接受了某种形式的激光屈光手术，以减少他们对矫正眼睛佩戴的依赖。激光屈光手术带来的角膜重塑为患者带来了极佳的视觉效果，但使目前的技术无法准确测量重塑后的角膜的力量。准确测量角膜屈光度在预测白内障手术后所需人工晶状体屈光度等应用中至关重要，这类患者在步入成年后期总是会遇到这一事件。我们提出的基于运动校正的高速光谱域光学相干断层扫描(SDOCT)的设备可以直接绘制微米级分辨率的角膜表面图，然后准确地将这些数据转换为角膜曲率值，这将极大地帮助依赖于该值的临床应用。主要的创新将是开发新的硬件和软件方法，以解决患者的非自愿运动和OCT光在角膜中的折射。然后，将对接受激光屈光手术的患者进行临床比较，以比较SDOCT和现有临床仪器测量角膜屈光度的结果。 公共卫生相关性：我们建议使用光谱域光学相干断层扫描技术开发一种改进的眼眼前段成像系统。如果成功，该项目可能会支持SDOCT作为眼科护理服务的首选单平台眼前段成像设备的广泛采用。

DESCRIPTION (provided by applicant): Accurate quantitative imaging of the cornea is critical for predictable outcomes in corneal based surgical interventions. While long the standard, reflection based corneal topography to assess corneal curvature and refractive power is insufficient in an era when surgical manipulation of the corneal shape is routine and undermines the basis of reflection topography. Laser refractive surgery is one particular corneal intervention that has revealed current inadequacies in measuring the cornea. Over 7 million people in the United States have had some form of laser refractive surgery to reduce their dependence on corrective eye wear. The corneal reshaping that occurs from laser refractive surgery results in excellent visual results for the patient but renders current technologies incapable of accurately measuring the power of the reshaped cornea. Accurate measurement of corneal power is critical in applications such as the prediction of intraocular lens power needed after cataract surgery, an event which this group of patients will invariably encounter as they age into late adulthood. Our proposed development of a motion corrected high-speed spectral domain optical coherence tomography (SDOCT) based device which can directly map corneal surfaces at micron resolution and then accurately convert this data to keratometric values will greatly aid clinical applications dependent on this value. The primary innovations will be the development of novel hardware and software methods to account for involuntary patient motion and for refraction of OCT light within the cornea. A clinical comparison will then be made in patients undergoing laser refractive surgery to compare the measurements made by SDOCT versus existing clinical instrumentation for the measurement of corneal power. PUBLIC HEALTH RELEVANCE: We propose to develop an improved ocular anterior segment imaging system using spectral domain optical coherence tomography. If successful, this project could support widespread adoption of SDOCT as the preferred, single-platform anterior segment imaging device in eye care delivery.