Urological Complications of Obesity and Diabetes

描述(申请人提供)：糖尿病(DM)是一种使人衰弱、代价高昂的疾病，可导致多种严重的并发症，以及过早死亡。糖尿病和肥胖会影响所有下尿路(LUT)的功能和结构，包括膀胱、尿路和前列腺；并可能导致尿失禁、排空障碍和性功能障碍等并发症。在被诊断为糖尿病的患者中，高达80%的人出现了泌尿系统并发症，这一比例高于公认的神经病变和肾病等并发症。PIS和他们的团队已经广泛研究了I型糖尿病(T1 DM)的LUT症状，包括糖尿病膀胱功能障碍(DBD)的特征、前列腺生长以及在啮齿动物模型中蛋白质组水平的分子靶点的确定。基于这些发现并响应RFA-DK-10-001，我们建议成立凯斯西部储备大学肥胖和糖尿病泌尿系统并发症跨学科研究中心(UCOD)。该中心的成立将：a)使我们与来自6个不同研究团队的现有研究人员的跨学科合作正式化；b)将我们的工作扩展到肥胖症和2型DM的研究；以及c)为奥布莱恩泌尿外科研究中心未来提交的重点是UCOD的建议提供大量的初步数据，UCOD是影响我国的最常见的良性泌尿系统疾病之一。 拟议的中心将包括一项研究提案，它将作为我们在UCOD方面跨学科工作的科学路线图；一个行政核心，将规划和实施中心的短期和长期目标；以及一个创新的丰富计划，允许我们与其他50名初级和成熟的研究人员、博士后(博士和MD)研究员和学生分享我们在UCOD方面的工作，并为将在我们中心工作12个月的两名研究学者的工作提供机构支持。CWRU关于UCOD的中心得到了CWRU和包括大克利夫兰糖尿病协会在内的地区科学界的大力支持。这一水平的支持将确保我们的中心成熟为地区良性泌尿系统疾病跨学科研究中心(IR-BU)，这是RFA-DK-10-001的最终目标。 与公共健康相关：糖尿病和肥胖症目前在美国呈上升趋势，可能会导致严重的泌尿系统并发症。对肥胖和糖尿病的泌尿系统并发症(UCOD)的跨学科研究将促进改善和创新UCOD的治疗或预防方法，UCOD是影响我国的一些最常见的良性泌尿系统疾病。

DESCRIPTION (provided by applicant): Diabetes mellitus (DM) is a spectrum of debilitating, costly diseases that can lead to multiple and serious complications, as well as premature death. Diabetes and obesity impact the function and structure of all the lower urinary tract (LUT) including bladder, urethral, and prostate; and can lead to complications such as urinary incontinence, poor emptying, and sexual dysfunction. Urologic complications are found in up to 80% of individuals diagnosed with DM, a higher rate than that of widely recognized complications such as neuropathy and nephropathy. The PIs and their teams have extensively studied LUT symptoms of type I DM (T1DM), including characterization of diabetic bladder dysfunction (DBD), prostate growth, and identification of molecular targets at the proteome level in the rodent models. Based on those findings and in response to RFA-DK-10-001, we propose to form the Case Western Reserve University Interdisciplinary Research Center on Urological Complications of Obesity and Diabetes (UCOD). The formation of the Center will: a) formalize our existing interdisciplinary collaboration with established investigators from 6 different research teams; b) expand our work into studies of obesity and type 2 DM; and c) produce high volume preliminary data for future submission of proposals for O'Brien Urology Research Center focusing on UCOD, as one of the most common Benign Urological Diseases affecting our nation. The proposed Center will consist of a research proposal that will function as the scientific road map for our interdisciplinary work on UCOD; an Administrative Core that will plan and implement the short and long term objectives of the Center; and an innovative Enrichment Program that would allow us to share our work on UCOD with 50 other junior and established investigators, post-doctoral (PhD and MD) fellows, and students and provide Institutional support for the work of two Research Scholars who would spend 12 months in our Center. The CWRU Center on UCOD is strongly supported by the CWRU and regional scientific community including the Diabetic Association of Greater Cleveland. This level of support will assure maturation of our Center into a regional Center of Interdisciplinary Research in Benign Urological Disease (IR-BU), the ultimate aim of the RFA-DK-10-001. PUBLIC HEALTH RELEVANCE: Diabetes and obesity, currently on the rise in the U.S., can lead to serious urologic complications. Interdisciplinary studies on the Urologic Complications of Obesity and Diabetes (UCOD) will foster improved and innovative approaches to treatment or prevention of UCOD, which are some of the most common benign urologic diseases affecting our nation.