行政核心-猫眼课题宝

行政核心

批准号：

7983570

负责人：

James R. Heath

金额：

$11.61万

依托单位：

CALIFORNIA INSTITUTE OF TECHNOLOGY

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-09-03 至 2015-07-31

来源：

https://reporter.nih.gov/project-details/7983570

关键词：

Address Animal Model Animals Area Atlases Back Baltimore Basic Science Belgium Biochemistry Bioinformatics Biological Biological Assay Biological Markers Biological Models Biology Blood Blood Proteins Brain Brain Neoplasms CCNE1 gene Cancer Biology Cancer Center Cancer Model Cancer Patient Cancer cell line Cell Culture Techniques Cell Line Cells Chemicals Chin Clinic Clinical Clinical Sciences Clinical Services Clinical Trials Collaborations Collection Commit Communities Complement Complex Comprehensive Cancer Center Computational Technique Core Facility DNA Data Data Set Development Devices Diagnosis Diagnostic Discipline of Nuclear Medicine Doctor of Philosophy Engineering Enrollment Environment Enzymes Epigenetic Process Evaluation Fostering Foundations Fresh Tissue Funding Gene Mutation Gene Transduction Agent Generations Genes Genetic Genomics Glioblastoma Glioma Grant Gynecologic Oncology Gynecologic Oncology Group Heterogeneity Home environment House mice Human Human Resources Image Imaging technology Immune system Immunologic Monitoring Immunologist Immunology Immunotherapy In Vitro Individual Institutes Ions Jonsson Comprehensive Cancer Center of University of California Los Angeles Kinetics Label Laboratories Letters Luxembourg Malignant - descriptor Malignant Neoplasms Malignant neoplasm of ovary Manuscripts Mass Spectrum Analysis Measurement Mechanics Medical Melanoma Cell Mentors Metabolic Metabolism Methodology Microfluidics Mission Modeling Molecular Molecular Analysis Molecular Biology Molecular Medicine Monitor Mus Nanotechnology Operating Rooms Operative Surgical Procedures Organ Pathologist Pathology Pathway Analysis Pathway interactions Patients Pharmacodynamics Pharmacology Physicians Population Heterogeneity Positron-Emission Tomography Principal Investigator Process Prodrugs Property Proteins Proteomics RNA Interference Radiochemistry Regenerative Medicine Reproduction spores Research Research Personnel Resistance Resources Sampling Scientist Screening procedure Serum Signal Transduction Small Interfering RNA Solid Specific qualifier value Stem Cell Research Sum Support System System Systems Biology T-Lymphocyte Techniques Technology Therapeutic Tissue Banking Tissue Banks Tissue Harvesting Tissue Microarray Tissue Sample Tissues Touch sensation Tracer Training Programs Transcript Transgenic Mice Transgenic Organisms Translating Translations Tumor Stem Cells Tumorigenicity United States National Institutes of Health Ursidae Family Validation Vision Work Xenograft Model anticancer research base cancer cell cancer diagnosis cancer genome cancer immunotherapy cancer stem cell cancer therapy career development chemical synthesis clinically relevant commercialization cost design experience experimental analysis flexibility gene therapy gene therapy clinical trial human subject image reconstruction imaging probe improved in vivo in vivo Cellular and Molecular Imaging Centers in vivo Model innovation instrumentation medical specialties meetings melanoma minimally invasive molecular imaging mouse model nano nanofluidic nanoparticle neuro-oncology novel novel therapeutics oncology optical imaging pharmacokinetic model physical science pre-clinical programs prototype resistance mechanism small hairpin RNA stem cell biology success targeted delivery technology development tissue culture tool tumor tumor growth

项目摘要

项目成果

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中文摘要

翻译

描述了NSBCC管理核心。NSBCC由Jim Heath执导，迈克·菲尔普斯和勒罗伊·胡德。希思对该中心负全面责任，并具体负责技术开发组件。胡德博士对生物学的监督负有特殊责任 (and系统生物学）项目组成部分，Phelps博士监督NSBCC的临床翻译项目NSBCC的每一位领导者都在技术开发、临床应用、翻译和技术商业化。NSBCC领导人以内部审查为指导理事会由项目主要调查员和外部咨询委员会组成。的描述这是指导。个人的科学和人员组成如何项目提供了一种文化，在这种文化中，各组成部分的总和大于所提供的部分- 包括一个经过验证的愿景，加速技术创新的过程，以临床示范。与NCI资助的项目建立了重要的合作伙伴关系，包括琼森综合癌症中心，描述了利用基金会资助的项目和机构，如布罗德研究所，再生医学，进行了讨论。基金会和其他资源提供的额外资金 NSBCC项目的重要杠杆作用，并大大加快了我们进入诊所的途径。与营利性公司（Sofie Biosciences、Integrated Diagnostics和Momentum）建立更多合作伙伴关系生物科学）进行了描述。这些合作伙伴关系如何已经导致商业的例子 NSBCC技术的发展（从现有的CCNE资金）。

英文摘要

The NSBCC administrative Core is described. The NSBCC is Directed by Jim Heath and co-Directed by Mike Phelps & Leroy Hood. Heath bears overall responsibility for the center, and specific responsibility for the technology development components. Dr. Hood bears specific responsibility for oversight of the biology (and systems biology) project components, and Dr. Phelps oversees the clinical translation of NSBCC projects. Each of the NSBCC leaders has extensive expertise in technology development, clinical translation, and technology commercialization. The NSBCC Leaders are guided by an Internal Review Council comprised of the Project Principal Investigators, and by an External Advisory Board. Descriptions of that guidance are provided. Rationale for how the scientific and personnel composition of the individual projects provide for a culture in which the sum of the components is greater than the parts is given - including a proven vision for accelerating the process of technology innovation to clinical demonstration. Significant partnerships with NCI funded programs, including the Jonsson Comprehensive Cancer Center, are described. Leverage from foundation funded programs and institutes, such as the Broad Institute for Regenerative Medicine, are discussed. Additional funding from foundation and other resources provides significant leverage for the NSBCC projects, and significantly accelerates our pathway into the clinic. Additional partnerships with for-profit companies (Sofie Biosciences, Integrated Diagnostics, and Momentum Biosciences) are described. Examples of how these partnerships are already leading to the commercial development of NSBCC technologies (from existing CCNE funding) are provided.

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