Imaging Core

成像核心 东北大学转化神经成像中心的成像能力 提供了独特的能力，在体内的纳米制剂的可视化。该中心目前拥有高分辨率microSPECT/CT（NanoSPECT/CT，Bioscan，Inc.）和7 T MR系统（BioSpec， Bruker Biospin，Inc.）今年第四季度将安装microPET。凭借丰富的经验， 基于肿瘤的成像协议，成像核心能够通过SPECT和PET以及用于对比的纳米制剂来评估放射性标记的纳米制剂的动力学和动力学 增强MR研究。多模式数据采集支持药物开发、干预监测、疾病诊断和跟踪以及功能成像等项目。除了仪器和协议的发展，核心提供了一个图书馆的分析功能的疾病动物模型的纵向研究。这种功能集中于通过标准的体内和离体生物分布分析以及新的子器官和子肿瘤分布指标来跟踪纳米制剂。 该核心将数据和分析结果托管在一个基于网络的数据存储和分析中心上，该中心专用于临床前纵向成像研究。教师和合作研究人员可以通过基于网络的存储库沿着实时访问数据，并具有远程调度和研究计划功能。

Imaging Core The imaging capabilities at the Center for Translational Neuroimaging at Northeastern University offer unique capabilities for the visualization of nanopreparations in vivo. The center currently houses a high-resolution microSPECT/CT (NanoSPECT/CT, Bioscan, Inc.) and a 7T MR system (BioSpec, Bruker Biospin, Inc.) with a microPET to be installed in Q4 of this year. With extensive experience in onco-based imaging protocols, the imaging core enables the assessment of kinetics and dynamics of radio-labeled nanopreparations via SPECT and PET as well as nanopreparations for contrast enhanced MR studies. Multi-modal data acquisition support projects in drug development, intervention monitoring, disease diagnosis and tracking, and functional imaging. In addition to instrumentation and protocol development, the core offers a library of analysis functions for longitudinal studies of animal models of disease. Such functionality focuses on the tracking of nanopreparations via standard in vivo and ex vivo biodistribution analysis as well as novel sub-organ and sub-tumor metrics of distribution. The core hosts data and analysis results on a web-based data storage and analysis center dedicated to pre-clinical longitudinal imaging studies. Faculty and collaborating researchers have real-time access to data via the web-based repository along with remote scheduling and study-planning capabilities.