MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一份分包合同，旨在了解人类青春期开始的生理机制。在Dr. Ojeda实验室进行的研究是根据主要申请的具体目标3提出的研究，即：“在不存在干扰睾丸激素反馈的情况下，确定1）婴儿期脉冲式GnRH释放抑制和2）发育幼年期结束时脉冲式GnRH释放复苏时下丘脑基因表达的总体特征”。恒河猴被用作实验范例。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a subcontract aimed at understanding the physiological mechanisms responsible for the onset of puberty in humans. Studies performed in Dr. Ojeda's lab are those proposed under Specific Aim 3 of the main application, which is: "To determine, in the absence of interfering testicular hormone feedback, the global profile of hypothalamic gene expression at the time of 1) the suppression of pulsatile GnRH release during infancy, and 2) the resurgence in pulsatile GnRH release at the end of the juvenile phase of development". The rhesus monkey is being used as an experimental paradigm.