MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY

下丘脑青春期的分子和结构基础

• 批准号: 8357754
• 负责人: Sergio R Ojeda
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357754
• 关键词: Adolescent; Development; Feedback; Funding; Gene Expression; Genes; Grant; Human; Hypothalamic structure; Macaca mulatta; Molecular; National Center for Research Resources; Pattern; Phase; Physiological; Primates; Principal Investigator; Puberty; Research; Research Infrastructure; Resources; Source; Testicular Hormones; Time; Transcription Repressor/Corepressor; United States National Institutes of Health; base; cost; infancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a subcontract aimed at understanding the physiological mechanisms responsible for the onset of puberty in humans. Studies performed in this lab are those proposed under Specific Aim 3 of the main application, which is: "To determine, in the absence of interfering testicular hormone feedback, the global profile of hypothalamic gene expression at the time of 1) the suppression of pulsatile GnRH release during infancy, and 2) the resurgence in pulsatile GnRH release at the end of the juvenile phase of development". The rhesus monkey is being used as an experimental paradigm. Results obtained identified genes encoding transcriptional repressors as being potentially involved in regulating the developmental pattern of GnRH release in rhesus macaques.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这是一个旨在了解负责在人类青春期开始的生理机制。本实验室进行的研究是根据主要申请的具体目标3提出的研究，即：“在不存在干扰睾丸激素反馈的情况下，确定1）婴儿期脉冲式GnRH释放抑制和2）发育幼年期结束时脉冲式GnRH释放复苏时下丘脑基因表达的总体特征”。恒河猴被用作实验范例。获得的结果确定基因编码转录抑制因子作为潜在参与调节恒河猴GnRH释放的发育模式。