MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这是一个分包合同，旨在了解导致人类青春期开始的生理机制。本实验室进行的研究是在主要应用的特定目标3下提出的，即：“在没有干扰睾丸激素反馈的情况下，确定下丘脑基因表达的全球概况：1)婴儿时期GnRH脉动性释放的抑制，以及2)幼年发育阶段末期脉动性GnRH释放的回升”。恒河猴被用作实验范例。结果发现，编码转录抑制因子的基因可能参与调节恒河猴GnRH释放的发育模式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a subcontract aimed at understanding the physiological mechanisms responsible for the onset of puberty in humans. Studies performed in this lab are those proposed under Specific Aim 3 of the main application, which is: "To determine, in the absence of interfering testicular hormone feedback, the global profile of hypothalamic gene expression at the time of 1) the suppression of pulsatile GnRH release during infancy, and 2) the resurgence in pulsatile GnRH release at the end of the juvenile phase of development". The rhesus monkey is being used as an experimental paradigm. Results obtained identified genes encoding transcriptional repressors as being potentially involved in regulating the developmental pattern of GnRH release in rhesus macaques.