MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY

下丘脑青春期的分子和结构基础

• 批准号: 8357754
• 负责人: Sergio R Ojeda
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357754
• 关键词: Adolescent; Development; Feedback; Funding; Gene Expression; Genes; Grant; Human; Hypothalamic structure; Macaca mulatta; Molecular; National Center for Research Resources; Pattern; Phase; Physiological; Primates; Principal Investigator; Puberty; Research; Research Infrastructure; Resources; Source; Testicular Hormones; Time; Transcription Repressor/Corepressor; United States National Institutes of Health; base; cost; infancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is a subcontract aimed at understanding the physiological mechanisms responsible for the onset of puberty in humans. Studies performed in this lab are those proposed under Specific Aim 3 of the main application, which is: "To determine, in the absence of interfering testicular hormone feedback, the global profile of hypothalamic gene expression at the time of 1) the suppression of pulsatile GnRH release during infancy, and 2) the resurgence in pulsatile GnRH release at the end of the juvenile phase of development". The rhesus monkey is being used as an experimental paradigm. Results obtained identified genes encoding transcriptional repressors as being potentially involved in regulating the developmental pattern of GnRH release in rhesus macaques.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 这是一项分包合同，旨在理解负责人类青春期开始的生理机制。在本实验室进行的研究是主要应用的特定目的3提出的研究，即：“在没有干扰睾丸激素反馈的情况下，确定下丘脑基因表达在1）抑制脉冲GNRH在婴儿期释放时的全球概况，以及2）在脉冲Gnrh释放中的脉动释放中的重新释放。恒河猴被用作实验范式。获得的结果已鉴定出编码转录阻遏物的基因可能参与调节恒河猕猴中GnRH释放的发育模式。