NEUROENDOCRINE CONTROL OF OVARIAN DEVELOPMENT

卵巢发育的神经内分泌控制

基本信息

  • 批准号:
    8357724
  • 负责人:
  • 金额:
    $ 5.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This ongoing project is examining the hypothesis that growth factor molecules known as neurotrophins, and chemical messengers required for the development and mature function of the nervous system are produced by the mammalian ovary and contribute to regulating critical developmental phases in the natural history of the gland. The analysis of mutant mice carrying deletions of the genes encoding either neurotrophins or their recognition molecules (i.e., the neurotrophin receptors) showed that these growth factors are required for early development of ovarian follicles (the structural and functional unit of the ovary). In addition to neurotrophins, the ovary produces a variety of the same chemical messengers required for neuron-to-neuron communication in the nervous system. These messengers, known as neurotransmitters, appear to contribute to the process by which follicles become differentiated during early development and acquire the capability of responding to those hormones that -- secreted by the pituitary gland -- control the growth of mature follicles before puberty and during adult reproductive life. We are currently carrying out studies aimed at defining the cell types able to recognize neurotrophins during ovarian development, and are using genetic means to define the importance of these recognition molecules in ovarian development, including ovulation. We are also investigating the hypothesis that an excess of neurotrophins is deleterious, instead of beneficial, to ovarian function.
这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的, 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量, 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这个正在进行的项目正在研究一种假设,即称为神经营养素的生长因子分子和神经系统发育和成熟功能所需的化学信使是由哺乳动物卵巢产生的,并有助于调节腺体自然史中的关键发育阶段。对携带编码神经营养蛋白或其识别分子的基因缺失的突变小鼠的分析(即,神经营养素受体)表明这些生长因子是卵泡(卵巢的结构和功能单位)早期发育所必需的。除了神经营养素,卵巢还产生神经系统中神经元间通讯所需的各种相同的化学信使。这些信使被称为神经递质,似乎有助于卵泡在早期发育期间分化的过程,并获得对脑下垂体分泌的激素做出反应的能力,这些激素控制青春期前成熟卵泡的生长。和成人生殖生活期间。我们目前正在进行旨在确定能够在卵巢发育过程中识别神经营养因子的细胞类型的研究,并正在使用遗传方法来确定这些识别分子在卵巢发育(包括排卵)中的重要性。我们也在研究过量的神经营养素对卵巢功能有害而非有益的假说。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Sergio R Ojeda其他文献

Sergio R Ojeda的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Sergio R Ojeda', 18)}}的其他基金

Altering Energy Balance by Systemic Delivery of RNAi to the Neuroendocrine Brain
通过将 RNAi 系统性递送至神经内分泌脑来改变能量平衡
  • 批准号:
    8539523
  • 财政年份:
    2012
  • 资助金额:
    $ 5.82万
  • 项目类别:
Altering Energy Balance by Systemic Delivery of RNAi to the Neuroendocrine Brain
通过将 RNAi 系统性递送至神经内分泌脑来改变能量平衡
  • 批准号:
    8427058
  • 财政年份:
    2012
  • 资助金额:
    $ 5.82万
  • 项目类别:
NOVEL MECHANISMS UNDERLYING THE TRANSSYNAPTIC CONTROL OF LHRH RELEASE
LHRH 释放的跨突触控制的新机制
  • 批准号:
    8357725
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
NEURAL CONTROL OF THE PREPUBERTAL OVARY
青春期前卵巢的神经控制
  • 批准号:
    8357880
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
NEUROENDOCRINOLOGY OF PUBERTY AND SEXUAL DEVELOPMENT
青春期和性发育的神经内分泌学
  • 批准号:
    8357881
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
NEUROENDOCRINE CONTROL OF FEMALE PUBERTY
女性青春期的神经内分泌控制
  • 批准号:
    8357726
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
MOLECULAR AND STRUCTURAL BASES OF HYPOTHALAMIC PUBERTY
下丘脑青春期的分子和结构基础
  • 批准号:
    8357754
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
RNA INTERFERENCE THERAPY FOR HUNTINGTON'S DISEASE: STUDIES IN NON-HUMAN PRIMATES
亨廷顿病的 RNA 干扰疗法:在非人类灵长类动物中的研究
  • 批准号:
    8357819
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
INTRODUCING STABLE INFERTILITY BY RNA INTERFERENCE
通过 RNA 干扰引入稳定的不孕症
  • 批准号:
    8357818
  • 财政年份:
    2011
  • 资助金额:
    $ 5.82万
  • 项目类别:
NEUROENDOCRINE CONTROL OF OVARIAN DEVELOPMENT
卵巢发育的神经内分泌控制
  • 批准号:
    8173170
  • 财政年份:
    2010
  • 资助金额:
    $ 5.82万
  • 项目类别:

相似海外基金

PINK - Provision of Integrated Computational Approaches for Addressing New Markets Goals for the Introduction of Safe-and-Sustainable-by-Design Chemicals and Materials
PINK - 提供综合计算方法来解决引入安全和可持续设计化学品和材料的新市场目标
  • 批准号:
    10097944
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    EU-Funded
Safe and Sustainable by Design framework for the next generation of Chemicals and Materials
下一代化学品和材料的安全和可持续设计框架
  • 批准号:
    10110559
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    EU-Funded
The University of Liverpool and Pegasus Chemicals Limited KTP 22_23 R5
利物浦大学和飞马化学有限公司 KTP 22_23 R5
  • 批准号:
    10063790
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Knowledge Transfer Partnership
Removal of Perfluorinated Chemicals Using New Fluorinated Polymer Sorbents
使用新型氟化聚合物吸附剂去除全氟化化学品
  • 批准号:
    LP220100036
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Linkage Projects
Optimising Nature's pharmacies: plant chemicals and pollinator health at the landscape scale
优化大自然的药房:景观尺度上的植物化学物质和传粉媒介健康
  • 批准号:
    NE/Y000285/1
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Research Grant
Building Synthetic Biofilm Consortia for Polyfluorinated Chemicals Biodegradation
建立多氟化学品生物降解合成生物膜联盟
  • 批准号:
    2343831
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Standard Grant
CAS-SC: Tuning Hydrocarbon Products from Temperature-Gradient Thermolysis of Polyolefins and the Subsequent Upcycling to Functional Chemicals
CAS-SC:调整聚烯烃温度梯度热解的碳氢化合物产品以及随后升级为功能化学品
  • 批准号:
    2411680
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Standard Grant
Converting lignin condensed structures into high-value polyaromatic hydrocarbon chemicals by controlled pyrolysis
通过受控热解将木质素缩合结构转化为高价值的多芳烃化学品
  • 批准号:
    24K17940
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
INSIGHT: Integrated Models for the Development and Assessment of High Impact Chemicals and Materials
洞察力:高影响化学品和材料开发和评估的综合模型
  • 批准号:
    10097888
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    EU-Funded
ELectrochemical OXidation of cYclic and biogenic substrates for high efficiency production of organic CHEMicals (ELOXYCHEM)
用于高效生产有机化学品的循环和生物底物的电化学氧化 (ELOXYCHEM)
  • 批准号:
    10110221
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    EU-Funded
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了