NEUROENDOCRINE CONTROL OF OVARIAN DEVELOPMENT

卵巢发育的神经内分泌控制

• 批准号: 8357724
• 负责人: Sergio R Ojeda
• 金额: $ 5.82万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357724
• 关键词: Adult; Chemicals; Communication; Development; Funding; Gene Deletion; Genetic; Gland; Graafian Follicles; Grant; Growth; Growth Factor; Hormones; Life; Mutant Strains Mice; National Center for Research Resources; Natural History; Nerve Growth Factor Receptors; Nervous System Physiology; Nervous system structure; Neurons; Neurosecretory Systems; Neurotransmitters; Ovarian; Ovarian Follicle; Ovary; Ovulation; Phase; Pituitary Gland; Primates; Principal Investigator; Process; Puberty; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cell type; cost; neurotrophic factor; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This ongoing project is examining the hypothesis that growth factor molecules known as neurotrophins, and chemical messengers required for the development and mature function of the nervous system are produced by the mammalian ovary and contribute to regulating critical developmental phases in the natural history of the gland. The analysis of mutant mice carrying deletions of the genes encoding either neurotrophins or their recognition molecules (i.e., the neurotrophin receptors) showed that these growth factors are required for early development of ovarian follicles (the structural and functional unit of the ovary). In addition to neurotrophins, the ovary produces a variety of the same chemical messengers required for neuron-to-neuron communication in the nervous system. These messengers, known as neurotransmitters, appear to contribute to the process by which follicles become differentiated during early development and acquire the capability of responding to those hormones that -- secreted by the pituitary gland -- control the growth of mature follicles before puberty and during adult reproductive life. We are currently carrying out studies aimed at defining the cell types able to recognize neurotrophins during ovarian development, and are using genetic means to define the importance of these recognition molecules in ovarian development, including ovulation. We are also investigating the hypothesis that an excess of neurotrophins is deleterious, instead of beneficial, to ovarian function.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这个正在进行的项目正在研究一种假设，即称为神经营养素的生长因子分子和神经系统发育和成熟功能所需的化学信使是由哺乳动物卵巢产生的，并有助于调节腺体自然史中的关键发育阶段。对携带编码神经营养蛋白或其识别分子的基因缺失的突变小鼠的分析（即，神经营养素受体）表明这些生长因子是卵泡（卵巢的结构和功能单位）早期发育所必需的。除了神经营养素，卵巢还产生神经系统中神经元间通讯所需的各种相同的化学信使。这些被称为神经递质的信使似乎有助于卵泡在早期发育过程中分化的过程，并获得对垂体分泌的激素做出反应的能力，这些激素控制青春期前和成年生殖期成熟卵泡的生长。我们目前正在进行旨在确定能够在卵巢发育过程中识别神经营养因子的细胞类型的研究，并正在使用遗传方法来确定这些识别分子在卵巢发育（包括排卵）中的重要性。我们也在研究过量的神经营养素对卵巢功能有害而非有益的假说。