SYNTHESIS AND BIOTRANSFORMATION OF ANTI-VIRAL PRODRUGS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正处于赠款的最后一年，将于2011年到期。 2009年，由于处理项目管理的研究项目协调员因慢性健康问题长期外出，随后离开实验室，动物工作停止。 因此，我们没有寻求批准延长IACUC方案用于我们的抗HIV前药工作。 如果该研究人员被替换，该项目将根据先前工作的结果恢复到最后一年，因为需要进一步研究来确定DAPD/DXG作为DXG前药的成功。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are in the last year of the grant, which will expire in 2011. Animal work in 2009 was halted when the research project coordinator handling the project administration was out for an extended period with a chronic health problem, subsequently leaving the laboratory. As a result, we did not pursue approval to extend the IACUC protocol for our work of anti-HIV prodrugs. If this researcher is replaced, the project will be re-instated for its final year based on the results of the preceding work since further studies are warranted to determine the success of DAPD/DXG as a DXG prodrug.