EARLY EVENTS IN MUCOSAL SIV PATHOGENESIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管多年的努力，有效的艾滋病毒疫苗仍然难以捉摸。也许设计有效疫苗的最大障碍是缺乏对保护免受感染和/或从受感染宿主清除病毒所必需的免疫应答的理解。此外，早期细胞和分子事件，特别是在HIV感染患者的粘膜组织中的事件知之甚少。 此外，关于HIV感染中最早的病毒学和免疫学事件以及免疫与感染或疾病进展的相关性仍然存在相当大的争议，这两者对于开发用于预防或控制感染的新型疫苗或免疫治疗剂都是至关重要的。拟议的研究将利用SIV感染的恒河猴模型来解决涉及肠道感染的最早期事件，以及粘膜免疫在控制感染中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite years of effort, an effective vaccine for HIV remains elusive. Perhaps the greatest obstacle to designing an effective vaccine is a lack of understanding of the immune responses necessary for protection from infection and/or clearance of virus from infected hosts. Furthermore, early cellular and molecular events, particularly in mucosal tissues of HIV infected patients are poorly understood. Further, considerable controversy remains with regard to the earliest virologic and immunologic events in HIV infection, and correlates of immunity to infection or disease progression, which are both critical for developing novel vaccines or immunotherapeutics for prevention or control of infection. The proposed studies will utilize the rhesus macaque model of SIV infection to address the earliest events involved in infection of the intestine, as well as the role of mucosal immunity in control of infection.