UREAPLASMA INFECTION IN UTERO: PREVENTION OF NEUROLOGIC SEQUELAE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本研究的目的是描述生殖器支原体引起的脑白色炎症和神经元损伤的程度（U。parvum），并评估母体抗生素加抗炎治疗在改善胎儿脑炎症和神经元损伤中的功效。我们的假设是，产前治疗U。使用特定抗生素和适当的抗炎剂治疗细小羊膜腔感染（IAI）将延迟早产并减轻新生儿脑白色物质损伤的胎儿起源。为了促进我们的研究，我们将建立一个特殊护理托儿所（SCN），以支持早产恒河猴的产后生存和特定的神经行为评估方案，以研究产后神经后遗症。在合作的学术兽医和ONPRC兽医的医学指导下，我们将制定重症监护管理计划，以及新生儿护理的标准操作程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this research are to delineate the extent of cerebral white matter inflammation and neuronal injury caused by genital mycoplasmas (U. parvum) and to assess the efficacy of maternal antibiotic plus anti-inflammatory therapy in ameliorating fetal brain inflammation and neuronal injury. It is our hypothesis that prenatal treatment of U. parvum intra-amniotic infection (IAI) with specific antibiotics and appropriate anti-inflammatory agents will delay preterm delivery and mitigate fetal origins of neonatal cerebral white matter injury. To facilitate our studies we will establish a special care nursery (SCN) that will support postnatal survival of prematurely born rhesus monkeys and specific neurobehavioral assessment protocols to study postnatal neurologic sequelae. With medical direction from collaborating academic neonatologists and ONPRC veterinarians, we will develop critical care management plans, as well as standard operating procedures neonatal care.