TARGETING HYALURONIDASES AS A STRATEGY TO REVERSE REMYELINATION FAILURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本基金的目的是：目的1：检验减少特定透明质酸酶的表达将促进化学诱导脱髓鞘病变中OL祖细胞成熟和髓鞘再生的假设。目标二：测试透明质酸酶活性的药理学抑制剂是否可以促进化学诱导的脱髓鞘病变和EAE小鼠中发生的病变的髓鞘再生

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this grant are to: Aim 1: Test the hypothesis that reducing the expression of specific hyaluronidases will promote OL progenitor maturation and remyelination in chemically-induced demyelinated lesions. Aim 2: Test if pharmacological inhibitors of hyaluronidase activity can promote remyelination in both chemically-induced demyelinated lesions and in lesions that occur in mice with EAE