SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

描述(申请人提供)：P51 RR00163-50资助金的5年续期 请求为ONPRC支持生物医学研究的项目提供资金。该应用程序反映了 新的战略重点是跨学科研究，以优化非人类的使用和发展 灵长类(NHP)模型。该应用程序的目标是：1)提供基础设施支持 有必要进行先进的生物医学研究，其中使用NHP来加快进展 在了解人类疾病方面；2)加强S中心的资源(科学知识、实验室、 动物服务、研究支持核心和设备)，以便作为区域和国家 资源；3)通过我们的支持，为生物医学研究增加定义的NHP的可用性 扩大SPF印度原种恒河猴繁育计划的计划；以及4)扩大研究 在干细胞生物学、衰老、肥胖症、遗传学、传染病、疫苗等领域利用NHP的项目 发展、神经科学和女性？S健康。为实现这些目标，需要在 主要有三个方面。首先，行政和中心运营提供行政和服务 ONPRC的所有方面都需要支持。单位包括：1)S主任办公室；2)行政 服务(商业服务、环境健康和辐射安全、设施和财产、 信息技术与工程和研究图书馆)；3)动物资源 (行政、营运、行为服务、病理服务、外科服务及临床 医学)；和4)研究支持核心(辅助生殖技术、内分泌技术、 成像与形态学、免疫学、磁共振成像、分子与细胞生物学，以及 病毒学和血清学)。第二，科学组成部分包括支持：1)科学分区 (神经科学、病理生物学与免疫学、生殖科学)及其交叉学科 工作组(衰老生物学、新陈代谢疾病和干细胞与发育生物学)；2) 促进外部资助研究的合作研究单位；3)试点项目计划； 4)资源相关研究。最后，改进和现代化包括资金用于 设备、改建和翻新。

DESCRIPTION (provided by applicant): The 5-year renewal for Grant P51 RR00163-50 requests funding for programs at the ONPRC that support biomedical research. The application reflects a new strategic focus on interdisciplinary research to optimize the use and development of nonhuman primate (NHP) models. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which NHPs are used to accelerate progress in understanding human diseases; 2) enhance the Center?s resources (scientific expertise, laboratories, animal services, research support cores and equipment) so as to serve as a regional and national resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-origin rhesus macaque breeding program; and 4) expand research programs utilizing NHPs in stem cell biology, aging, obesity, genetics, infectious diseases, vaccine development, neuroscience and women?s health. To accomplish these aims, support is requested in three broad areas. First, Administration & Center Operations provide the administrative and service support required for all aspects of the ONPRC. Units include: 1) the Director?s Office; 2) Administrative Services (Business Services, Environmental Health & Radiation Safety, Facilities & Property, Information Technology & Engineering, and the Research Library); 3) Animal Resources (Administration, Operations, Behavioral Services, Pathology Services, Surgery Services, and Clinical Medicine); and 4) Research Support Cores (Assisted Reproductive Technology, Endocrine Technology, Imaging & Morphology, Immunology, Magnetic Resonance Imaging, Molecular & Cellular Biology, and Virology & Serology). Secondy, Scientific Components include support for: 1) Scientific Divisions (Neuroscience, Pathobiology & Immunology, and Reproductive Sciences) and their interdisciplinary Working Groups (Biology of Aging, Metabolic Disease, and Stem Cell & Developmental Biology); 2) the Collaborative Research Unit that facilitates externally funded research; 3) the Pilot Project Program; and 4) Resource-Related Research. Finally, Improvement & Modernization includes funds for equipment and alterations and renovations.