Core-A Administative

Conte Center for the Neuroscience of Mental Disorders（CCNMD）提供了一个高度互动的科学 环境，整合了多个研究者的基础和临床研究活动， 匹兹堡大学的医学院、文理学院和邻近的卡内基梅隆大学 大学总的来说，CCNMD代表了广泛的专业知识，涵盖分子，系统， 认知，计算和临床神经科学，提供互补的方法来测试 中心假设，GABA神经元亚群中的分子改变的独特模式 （病理学）引起皮层网络振荡（病理生理学）的保守性干扰， 是精神分裂症核心信息处理缺陷（临床综合征）的基础。建议5 项目，由行政、临床服务和诊断以及统计和数据支持 管理核心，检查1）精神分裂症在不同的皮质亚群中的分子异常 GABA神经元被认为产生振荡活动（项目1-刘易斯）; 2）综合计算， 电生理学和解剖学方法来确定细胞类型特异性 皮层GABA神经传递和体外振荡（项目2-Ermentrout）; 3）GABA的作用 在非人类灵长类动物中， 精神分裂症中改变的信息处理域（项目3-Olson）; 4）特定类型的 精神分裂症中的信息处理障碍，与改变激活和受损 某些皮层区域的网络振荡（项目4-菲利普斯）;以及5）新PET的开发 用于研究体内人类皮层GABA神经元功能的成像工具（项目5-马西斯）。的 这些项目的协同作用和双向互动促进了一种转化方法， 精神分裂症研究，旨在确定基于病理生理学的新治疗靶点 干预措施和发展的病理生理学生物标志物，可用于监测疗效 这样的干预。因此，拟议中的中心是一个多学科的努力，旨在测试一个机械的 假设，以提高我们对疾病过程的核心组成部分的理解， 精神分裂症此外，该中心还提供1）丰富的培训和职业发展环境， 这些人可以参与研究，带来基本的方法和知识基础， 神经科学，以解决临床精神分裂症研究中的关键问题，和2）一个机制， 传播精神分裂症转化研究的重要性和从中获得的知识， 更广泛的科学界和非科学界。

This Conte Center for the Neuroscience of Mental Disorders (CCNMD) offers a highly interactive scientific environment that integrates the basic and clinical research activities of multiple investigators from the University of Pittsburgh's Schools of Medicine and Arts and Sciences and the adjacent Carnegie Mellon University. Collectively, the CCNMD represents a broad array of expertise spanning molecular, systems, cognitive, computational and clinical neuroscience that provides complementary approaches to testing the central hypothesis that a distinctive pattern of molecular alterations in subpopulations of GABA neurons (pathology) gives rise to conserved disturbances in cortical network oscillations (pathophysiology) that underlie the core information processing deficits (clinical syndrome) of schizophrenia. The proposed 5 projects, supported by Administrative, Clinical Services and Diagnostics, and Statistics and Data Management Cores, examine 1) molecular abnormalities in schizophrenia in distinct subsets of cortical GABA neurons thought to generate oscillatory activity (Project 1-Lewis); 2) integrated computational, electrophysiological and anatomical approaches to determine the relationship between cell type-specific cortical GABA neurotransmission and oscillations in vitro (Project 2-Ermentrout); 3) the role of GABA neurotransmission in cortical oscillations elicited by tasks that tap in non-human primates the same information processing domains that are altered in schizophrenia (Project 3-Olson); 4) specific types of information processing disturbances in schizophrenia that are linked to altered activation of, and impaired network oscillations in, certain cortical regions (Project 4-Phillips); and 5) the development of new PET imaging tools for studying the function of human cortical GABA neurons in vivo (Project 5-Mathis). The synergism and bi-directional interactions of these projects facilitates a translational approach to schizophrenia research directing at identifying pathophysiology-based targets for novel therapeutic interventions and developing biomarkers of the pathophysiology that can be used to monitor the efficacy of such interventions. Thus, the proposed Center is a multi-disciplinary effort directed at testing a mechanistic hypothesis in order to improve our understanding of a core component of the disease process of schizophrenia. In addition, the Center provides 1) a rich environment for training and career development in which individuals can become involved in studies that bring the methods and knowledge base of basic neuroscience to address critical questions in clinical schizophrenia research, and 2) a mechanism for disseminating the importance of, and the knowledge gained from, translational studies of schizophrenia to the broader scientific and lay communities.