Multimodal assessment of sensory processing dysfunction in schizophrenia

感觉加工缺陷是精神分裂症的一个重要组成部分。该项目将分析 用多模式成像方法研究感觉加工功能障碍的机制 结合神经生理学和基于MRL的评估。神经生理学研究 将评估神经元同步性和振荡性层级损伤在急性脑梗塞病因中的作用 神经认知功能障碍。特别是，它将检验这样一种假设，即非线性损伤 刺激放大和振荡夹带可能阻碍患者的反应优化 相对于控件。计划进行四个实验。第一个实验将分析 振荡性夹带在先前文献中记录的感觉加工缺陷和 客体注意障碍。在本实验中，将进行分层振荡分析 使用从项目2和3开发的数学方法和模拟范例， 分别进行了分析。第二个实验将分析空间注意在感觉加工中的作用。 功能障碍，也使用标准的ERP和振荡层次分析，还将 评估时相重置与外源性活动在患者和对照组的事件相关电位生成中的作用。 实验3将使用SSVEP方法进一步评估空间注意效应。中国的赤字 还将对照症状和认知措施来评估事件相关电位的生成。第四次 实验将评估结构和功能连接障碍在糖尿病病因中的作用。 使用由Core B支持的MR测量的感觉和注意力缺陷。DTI测量将是 用于评估结构连通性，而静息状态功能磁共振将用于评估功能 连通性。一个基本的假设是，神经生理过程中的缺陷，如非 已知的NMDA受体依赖的线性增益和慢振荡函数将导致 较高频率振荡(例如，Delta、Theta、Gamma)的夹带受损，导致 损害了事件相关电位的生成和行为。总体而言，该项目将检验以下假设： 区域内层次化处理和区域间结构和功能连通 导致精神分裂症患者的神经认知功能障碍。 相关性(请参阅说明)： 精神分裂症是一种主要的精神障碍。神经认知功能障碍是 精神分裂症是长期预后不佳的主要决定因素。该项目将评估 患者感觉加工障碍和神经认知功能障碍的潜在机制 慢性精神分裂症患者，与其他项目和核心计划合作，以便 制定改进的早期检测、诊断和干预方法。

Sensory processing deficits are a key component of schizophrenia. This project will analyze mechanisms underlying sensory processing dysfunction using a multimodal imaging approach incorporating both neurophysiological and MRl-based assessments. Neurophysiological studies will evaluate role of neuronal synchrony and oscillatory hierarchy impairments in etiology of neurocognitive dysfunction. In particular, it will test the hypothesis that impairments in non-linear stimulus amplification and in oscillatory entrainment may prevent response optimization in patients relative to controls. Four experiments are planned. The first experiment will analyze the role of oscillatory entrainment in the genesis of previously documented sensory processing deficits and object-attention dysfunction. For this experiment, hierarchical oscillatory analyses will be conducted using mathematical approaches and stimulation paradigms developed from Projects 2 and 3, respectively. The second experiment will analyze the role of spatial attention in sensory processing dysfunction, also using both standard ERP and oscillatory hierarchy analyses, and will also evaluate the role of phase reset vs. exogenous activity in ERP generation in patients and controls. Experiment 3 will evaluate spatial attention effects further using ssVEP approaches. Deficits in ERP generation will also be assessed relative to symptomatic and cognitive measures. The fourth experiment will evaluate the role of structural and functional connectivity impairments in etiology of sensory and attentional deficits using MR measures supported by Core B. DTI measures will be used to assess structural connectivity, while resting state fMRI will be used to assess functional connectivity. An underiying hypothesis is that deficits in neurophysiological processes such as non¿ linear gain and slow oscillatory function that are known to be NMDA receptor-dependent will lead to impaired entrainment of higher-frequency oscillations (e.g. delta, theta, gamma), leading to impaired ERP generation and behavior. Overall, this project will test the hypothesis that deficits in hierarchical processing within regions and structural and functional connectivity between regions lead to deficits in neurocognitive function in schizophrenia. RELEVANCE (See instructions): Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This project will evaluate mechanisms underlying deficits in sensory processing and neurocognitive dysfunction in patients with chronic schizophrenia, in collaboration with other projects and core programs in order to develop improved methods for early detection, diagnosis and intervention.