Research Methods Core

对于焦虑青年认知行为疗法(CBT)的变化机制，人们知之甚少。 可能是因为大多数治疗结果研究只关注诊断状态的变化和 症状，而不是使用多种方法来了解跨多个系统的更改 与恢复有关。使用跨学科的方法，该核心将为 检查症状、家庭和同伴环境中的行为、睡眠和大脑反应性的变化 焦虑儿童在CBT前、中、后的认知和情绪信息加工任务 和CCT。这些数据将用作对所有三个主要项目进行分析的基础。 具体地说，该核心描述了以下评估。治疗前后，参与者将 使用等级对临床状态、症状、情感风格和亲子互动的完整测量 量表、自我报告测量和行为观察。基因数据也将被获取。参与者 将完成认知和情感信息处理测量在功能磁共振成像和同时瞳孔 扩张/眼球跟踪评估，以及事件相关电位(ERP)评估。每两周一次 在整个治疗过程中，参与者将完成症状、瞳孔的自我报告评分 扩张/眼球跟踪评估，以及基于家庭的生态瞬时评估和睡眠 动作记录仪协议。该核心整合并监督所有项目的评估方法。的 尤其重要的是，提供了用于为每个主索引创建综合摘要索引的方法 评估领域，用于每个项目和跨项目分析，通过在核心开发的方法 3. 将这些方法集中在一个核心中，由一个项目协调员和一个集成的 测量方法对于这种CIDAR机制是必不可少的。集中管理这些 评估将1)有助于更好地了解这些评估如何结合在一起，2)促进 以后跨项目集成分析和结果，以及3)提高效率并减少参与者 以方便和有计划的方式整合评估，以减轻负担。

Little is known about the mechanisms of change in cognitive behavioral therapy (CBT) for anxious youth, potentially because most treatment outcome studies have focused only on changes in diagnostic status and symptoms, rather than using a multi-method approach to understand changes across multiple systems associated with recovery. Using a transdisciplinary approach, this core will provide an integrated structure for examining changes in symptoms, behavior in family and peer contexts, sleep, and brain reactivity to cognitive and emotional information processing tasks among anxious children before, during, and after CBT and CCT. These data will be used as the basis for analyses across all three of the primary projects. Specifically, this core describes the following assessments. Before and after treatment, participants will complete measures of clinical status, symptoms, affective style, and parent-child interactions using rating scales, self-report measures, and behavioral observations. Genetic data will also be acquired. Participants will complete cognitive and affective information processing measures during fMRI and concurrent pupil dilation/eyetracking assessment, as well as event-related potential (ERP) assessment. On a biweekly basis throughout treatment, participants will complete self-report ratings of symptomatology, pupil dilation/eyetracking assessments, and a home based Ecological Momentary Assessment and sleep actigraphy protocol. This core integrates and oversees the assessment methodologies for all projects. Of particular importance, methods are provided for creating composite summary indices for each primary domain of assessment, for use in each project and in cross-project analyses, via methods developed in Core 3. Having these methods centralized in a single core, with a single project coordinator, and an integrative measurement approach is essential for this CIDAR mechanism. Centralizing the administration of these assessments will 1) contribute to a better understanding of how these assessments fit together, 2) facilitate later integration of analyses and results across projects, and 3) increase efficiency and decrease participant burden by integrating assessments in a convenient and planful manner.