BEHAVIOR

行为核心的目的是评估创伤后神经回路的功能状态， 大鼠和小鼠脑损伤，通过定量评估感觉运动和认知行为终点 包括癫痫范例旨在评估与液体相关的神经行为缺陷 在大鼠中进行过度TBI，在小鼠中进行受控皮质撞击，并在可能的情况下评估两者之间的关系。 神经行为终点与神经病理学和神经生理学标记之间的关系。的考验 核心中使用的感觉运动整合和认知已被证明对 这些TBI模型产生的损伤，在中度至重度损伤严重程度下， 顶叶颞叶皮质、海马、丘脑和白色物质的病理学。

The purpose of the behavioral Core is to evaluate the functional status of neural circuitry following traumatic brain injury in rats and mice, by quantitatively assessing sensorimotor and cognitive behavioral endpoints including seizures. Paradigms are designed to assess neurobehavioral deficits associated with fluid percussive TBI in rats, and controlled cortical impact in mice, and to evaluate, when possible, the relation between neurobehavioral endpoints and neuropathological, and neurophysiological markers. The tests of sensorimotor integration and cognition used in the core are have been demonstrated to be sensitive to insults produced by these TBI models, which, at moderate to severe levels of injury severity, produce overt pathology in the parietotemporal cortex, hippocampus, thalamus, and white matter.