Administrative Core

圣安东尼奥哮喘和过敏性疾病合作研究中心的长期目标 （SA-AADCRC）行政核心（AC）是：提供项目的领导和总体协调 以及组成SA-AADCRC的核心，并促进研究者与其他 NIAID资助的AADCRC，使跨学科的专业知识和测试样品和试剂产生的 项目和核心资源共享，以实现最大影响和成本效益。SAAADCRC的主要重点 应用是鉴定和阐明肺炎支原体的作用及其独特的 社区获得性呼吸窘迫综合征ToXin（TOXin），一种真正的ADP核糖基化和 空泡毒素，并将其与新发哮喘，哮喘恶化和长期肺 儿童和成人的功能障碍。SA-AADCRC的成员包括来自 生物化学、微生物学和免疫学、医学、病理学和儿科学系以及 AC将继续支持这个紧密团结和合作的小组，并确保所有义务和 实现时间表，SA-AADCRC和NIAID之间的关系和沟通， 其他NIAID赞助的AADCRC是有效的，有益的和协作的。AC的具体目标是： 在研究者和NIAID之间SA-AADCRC活动的总体管理和协调中 工作人员和其他AADCRC;定期与项目和核心领导以及受训人员（毕业生和 医学生、博士后研究员和住院医师）评估战略和进展、需求和资源 分配;建议修改实验设计和研究方向与关键咨询 调查人员和国家信息和传播研究所;定期安排内部研究会议和工作进展会议 以及内部和外部演讲者研讨会;帮助财务管理和重新编制预算 各CRC项目和核心;审查手稿和进度报告;执行日常工作， 行政活动，以促进SA-AADCCRC以及整个 NIAID赞助的AADCRC成员;并促进翻译信息的转移（诊断， 治疗）UTHSCSA，NIAID和潜在的工业合作伙伴。额外的AC职责将 促进最大限度地利用资源，以开发新的和新颖的诊断和治疗方法， 治疗和预防急慢性哮喘和过敏性疾病。

The long term objectives of the San Antonio Asthma and Allergic Diseases Cooperative Research Center (SA-AADCRC) Administrative Core (AC) are: to provide leadership and overall coordination of the projects and cores that comprise the SA-AADCRC and to facilitate interactions between investigators and other NIAID-funded AADCRCs, so that cross-disciplinary expertise and test samples and reagents generated by projects and cores are shared for maximum impact and cost effectiveness. The major focus of the SAAADCRC application is to identify and elucidate the roles of Mycoplasma pneumoniae and its unique Community Acquired Respiratory Distress Syndrome ToXin (CARDS TX), a bona fide ADP ribosylating and vacuolating toxin, and link them to new-onset asthma, exacerbations of asthma, and long-term pulmonary dysfunction in children and adults. The membership of the SA-AADCRC includes investigators from the Departments of Biochemistry, Microbiology and Immunology, Medicine, Pathology, and Pediatrics and the AC will continue to support this closely knit and collaborative group and ensure that all obligations and timelines are achieved and that relationships and communication between the SA-AADCRC and NIAID and other NIAID-sponsored AADCRCs are efficient, helpful and collaborative. The AC specific aims are: assist in the overall management and coordination of activities ofthe SA-AADCRC among investigators and NIAID staff and other AADCRCs; meet regularly with project and core leadership and trainees (graduate and medical students, postdoctoral fellows and residents) to assess strategies and progress, needs and resource allocation; recommend modifications of experimental design and research direction in consultation with key investigators and NIAID; schedule regular in-house research conferences and work-in-progress sessions and internal and external speaker seminars; help in the financial management and re-budgeting of the respective CRC projects and cores; review manuscripts and progress reports; perform the day-to-day administrative activities in order to facilitate effectiveness of the SA-AADCCRC as well as of the entire NIAID-sponsored AADCRC members; and promote the transfer of translational information (diagnostics, therapeutics) to UTHSCSA, NIAID and potential industrial partners. Additional AC responsibilities will promote maximal usage of resources in order to develop new and novel diagnostics and therapeutics for the treatment and prevention of acute and chronic asthma and allergic diseases.