ACOSOG Competing Renewal

描述(由申请人提供)：ACOSOG是一个合作小组，由执业的内科、放射和外科肿瘤学家、诊断成像师、患者权益倡导者、病理学家、基础科学家、护士/CRA、统计学家和其他代表全美学术和社区实践的医疗保健专业人员组成。ACOSOG的目的是开发和评估创新的癌症治疗方法，其中癌症患者的手术管理发挥着关键作用。ACOSOG致力于通过一项创新的临床研究计划改善外科肿瘤学患者的护理，以达到三个具体目标：1.测试可提高反应和治愈率并减少与癌症护理相关的发病率和残疾的新疗法2.结合临床试验进行基础科学研究，以更好地了解疾病和治疗的生物学基础。3.支持个人成员和研究人员网络让患者参加试验，并履行ACOSOG的科学使命。 ACOSOG的科学组合侧重于针对ACOSOG试验的三个科学目标的研究：1)研究新的外科和靶向疗法，以维持肿瘤结果，同时减少毒副作用和残疾，提高生活质量；2)通过成像和分子图谱提高风险分层的准确性；以及3)通过新辅助疗法的应用，提高总体应答率和监测个体反应。科学议程由基础和翻译科学委员会和三个疾病委员会制定：乳房、胃肠道(GIST、胰腺和直肠)和胸科(肺和食道)，并由ACOSOG同行审查委员会维护和优先考虑。科学议程的多学科方法是通过全面整合所有模式和学科来实现的。成员的利益、需要和监督通过七个管理委员会的行动得到处理。为了实现ACOSOG的目标，该小组利用由三个关键组成部分组成的基础设施进行临床试验和相关研究，其中包括：1)位于北卡罗来纳州达勒姆的杜克临床研究所内的运营和成员中心(OMC)；2)位于明尼苏达州罗切斯特的统计和数据中心(SDC)，位于梅奥临床癌症中心内；以及3)位于密苏里州圣路易斯市的中央标本库(U24#5 U24 CA114736)。

DESCRIPTION (Provided by applicant): ACOSOG is a cooperative group comprised of practicing medical, radiation, and surgical oncologists, diagnostic imagers, patient advocates, pathologists, basic scientists, nurses/CRAs, statisticians, and other healthcare professionals representing academic and community practices throughout the U.S. The purpose of ACOSOG is to develop and evaluate innovative cancer therapies in which the surgical management of cancer patients plays a key role. ACOSOG Is dedicated to Improving the care of the surgical oncology patient through an Innovative clinical research program addressing three specific aims: 1. To test novel therapies that may increase response and cure rates and reduce morbidities and disabilities associated with cancer care 2. To conduct basic science studies in conjunction with clinical trials to better understand the biologic basis of diseases and treatments. 3. To support Individual members and investigator networks to accrue patients to trials and fulfill the scientific mission of ACOSOG. The scientific portfolio of ACOSOG is focused on investigations addressing three scientific aims for ACOSOG trials: 1) to investigate novel surgical and targeted therapies to maintain oncologic outcomes while reducing toxicities and disabilities and Improving quality of life; 2) to enhance the accuracy of risk stratification through imaging and molecular profiling; and 3) to Improve overall response rates and monitor Individual responses through the application of neoadjuvant therapies. The scientific agenda is established by the Basic and Translational Science Committee and the three Disease Committees: Breast, Gastrointestinal (GIST, pancreas, and rectum), and Thoracic (lung and esophagus) and maintained and prioritized by the ACOSOG Peer Review Committees. A multidisciplinary approach to the scientific agenda is accomplished through the comprehensive integration of all modalities and disciplines. Membership interests, needs, and oversight are attended to through the actions of seven Administrative Committees. To accomplish the goals of ACOSOG, the group conducts clinical trials and correlative studies using an infrastructure consisting of three critical components Including: 1) the Operations and Membership Center (OMC) located in Durham, NC, within the Duke Clinical Research Institute; 2) the Statistics and Data Center (SDC) located In Rochester, MN, within the Mayo Clinic Cancer Center; and 3) the Central Specimen Bank (U24 # 5 U24 CA114736) located in St. Louis, MO, within the Washington University.